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首页> 外文期刊>Scandinavian journal of infectious diseases. >Prevalence of drug resistance mutations and non-B subtypes in newly diagnosed HIV-1 patients in Denmark.
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Prevalence of drug resistance mutations and non-B subtypes in newly diagnosed HIV-1 patients in Denmark.

机译：丹麦新诊断的HIV-1患者中耐药突变和非B亚型的患病率。

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摘要

The aim of this study was to monitor the prevalence of drug resistance mutations in newly diagnosed HIV-1 positive individuals in Denmark. In addition we assessed the prevalence of non-B subtypes based on phylogenetic analysis of the pol gene. Plasma samples from 104 newly diagnosed HIV-1 positive patients were obtained in the year 2000. The entire protease gene and 320 amino acids of the reverse transcriptase gene were genotyped. Sequences were obtained from 97 patients. No subjects displayed primary resistance mutations in the protease gene, whereas all carried 1 or more secondary mutations. Resistance mutations in the RT-gene associated with NRTI-resistance were found in 1 patient, who was infected with zidovudine resistant HIV-1 harbouring the M41L mutation in combination with T215S and L210S. The T215S mutation has been showed to be associated with reversion of zidovudine resistance. The T215S mutation was found in 1 additional patient. The subtype distribution was subtype B 59%, C 18%, A 8%, CRF02_AG 5%, CRF01_AE 4%, D 3% and G 2%. We found 2 patients (2%) with mutations associated with resistance in the RT-gene and none in the protease gene indicating a low prevalence of resistant HIV-1 in Denmark in the year 2000.
机译：这项研究的目的是监测丹麦新诊断的HIV-1阳性个体中耐药性突变的发生率。此外，我们基于pol基因的系统发育分析，评估了非B亚型的患病率。在2000年获得了104名新诊断的HIV-1阳性患者的血浆样品。对整个蛋白酶基因和逆转录酶基因的320个氨基酸进行了基因分型。从97名患者获得序列。没有受试者在蛋白酶基因中显示出主要的抗性突变，而所有受试者都携带了1个或多个次级突变。在1名患者中发现了RT基因中与NRTI耐药相关的耐药突变，该患者感染了具有M41L突变并与T215S和L210S结合的齐多夫定耐药HIV-1。已经显示T215S突变与齐多夫定抗性的逆转有关。在另外1名患者中发现了T215S突变。亚型分布是亚型B 59％，C 18％，A 8％，CRF02_AG 5％，CRF01_AE 4％，D 3％和G 2％。我们发现2例（2％）的患者与RT基因中的耐药性相关突变，而蛋白酶基因中没有突变，表明2000年丹麦的HIV-1耐药性患病率较低。

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