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首页> 外文期刊>Scandinavian journal of infectious diseases. >Clinical progression in early and late stages of disease in a cohort of individuals infected with human immunodeficiency virus-2 in Guinea-Bissau.
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Clinical progression in early and late stages of disease in a cohort of individuals infected with human immunodeficiency virus-2 in Guinea-Bissau.

机译：在几内亚比绍，一群感染了人类免疫缺陷病毒2的个体在疾病早期和晚期的临床进展。

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The aim of this study was to assess the rate of clinical progression to early and late stages of human immunodeficiency virus-2 (HIV-2) infection. CD4 cell counts and other potential prognostic markers for disease progression were also evaluated. In January 1990 an open prospective cohort of police officers in Guinea-Bissau was initiated with yearly serological and clinical follow-up. Follow-up ended in June 1998. Symptoms were classified according to the World Health Organization staging system. The analysis included 148 HIV-2-seropositive subjects and 177 HIV-seronegative controls. 25 of the HIV-2-positive individuals were seroconverters (seroincident cases). The progression rate to stage 3 of HIV-2-positive subjects in stage 1+2 was 8.6/100 person-years (py) (rate ratio 6.2 compared with HIV-negative controls, 95% confidence interval 2.7-14.2, p < 0.001), and the progression rate to stage 4, i.e. acquired immunodeficiency syndrome (AIDS), was 2.1/100 py. HIV-2-positive people in stage 3 at inclusionprogressed to AIDS at a rate of 16.9/100 py. CD4% < or = 20 was found to be a significant prognostic marker for progression to stage 4, both from stage 1+2 and from stage 3. The clinical progression in this cohort of HIV-2-infected subjects was generally lower than that in HIV-1-positive cohorts.
机译：这项研究的目的是评估人类免疫缺陷病毒2（HIV-2）感染到早期和晚期的临床进展速度。还评估了疾病进展的CD4细胞计数和其他潜在的预后指标。 1990年1月，几内亚比绍开始了警务人员公开的预期队列研究，并进行了年度血清学和临床随访。随访于1998年6月结束。根据世界卫生组织分期系统对症状进行分类。该分析包括148名HIV-2血清阳性受试者和177名HIV血清阴性对照。 HIV-2阳性个体中有25人是血清转化者（发生血清事件的病例）。在1 + 2阶段，HIV-2阳性受试者进入3阶段的进展率为8.6 / 100人年（py）（与HIV阴性对照相比，比率为6.2，95％置信区间2.7-14.2，p <0.001 ），并且进入第4阶段（即获得性免疫缺陷综合症（AIDS））的进展率为2.1 / 100 py。处于感染期的第3阶段HIV-2阳性者进展为AIDS的比率为16.9 / 100 py。发现CD4％<或= 20是从1 + 2阶段和从3阶段进展到第4阶段的重要预后标志物。在这一受HIV-2感染的人群中，其临床进展通常低于在CD2％ HIV-1阳性人群。

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