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首页> 外文期刊>Scandinavian journal of medicine & science in sports. >Combined inhalation of beta2-agonists improves swim ergometer sprint performance but not high-intensity swim performance
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Combined inhalation of beta2-agonists improves swim ergometer sprint performance but not high-intensity swim performance

机译：联合吸入β2-激动剂可改善游泳测功仪的冲刺性能，但不能改善高强度游泳性能

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摘要

There is a high prevalence of asthma and airway hyperresponsiveness (AHR) in elite athletes, which leads to a major use of beta2-agonists. In a randomized double-blinded crossover study, we investigated the effects of combined inhalation of betaz-agonists (salbutamol, formoterol, and salmeterol), in permitted doses within the World Anti-Doping Agency 2013 prohibited list, in elite swimmers with (AHR, n = 13) or without (non-AHR, n = 17) AHR. Maximal voluntary isometric contraction of m. quadriceps (MVC), sprint performance on a swim ergometer and performance in an exhaustive swim test at 110% of VO_(2maX) were determined. Venous plasma interleukin-6 (IL-6) and interleukin-8 (IL-8) were measured post-exercise. No improvement was observed in the exhaustive swim test, but swim ergometer sprint time was improved (P < 0.05) in both groups from 57 +- 1.7 to 56 +- 1.8 s in AHR and 58.3 +- 1 to 57.4 +- 1 s in non-AHE. MVC and post-exercise plasma IL-6 increased (P < 0.05) with beta_2-agonists in both groups, whereas IL-8 only increased in AHR. In summary, inhalation of beta2-agonists, in permitted doses, did not improve swim performance in elite swimmers. However, swim ergometer sprint performance and MVC were increased, which should be considered when making future anti-doping regulations.
机译：精英运动员的哮喘和气道高反应性（AHR）患病率很高，这导致人们大量使用β2受体激动剂。在一项随机双盲交叉研究中，我们研究了在（AHR， n = 13）或不使用（非AHR，n = 17）AHR。 m的最大自愿等距收缩。确定股四头肌（MVC），游泳测功机上的冲刺性能以及在VO_（2maX）的110％时进行的详尽游泳测试的性能。运动后测量静脉血浆白细胞介素6（IL-6）和白细胞介素8（IL-8）。在详尽的游泳测试中未观察到改善，但两组的游泳测功仪的冲刺时间从AHR的57 +/- 1.7改善到56 +/- 1.8 s，AHR的58.3 +1到57.4 +1 s改善了（P <0.05）。非AHE。两组中的β_2受体激动剂使MVC和运动后血浆IL-6升高（P <0.05），而IL-8仅在AHR中升高。总之，以允许的剂量吸入β2-激动剂并不能改善精英游泳者的游泳成绩。但是，游泳测功仪的冲刺性能和MVC有所提高，这在制定未来的反兴奋剂规定时应予以考虑。

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