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首页> 外文期刊>Cerebral cortex >Early Differences in Axonal Outgrowth, Cell Migration and GABAergic Differentiation Properties between the Dorsal and Lateral Cortex.
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Early Differences in Axonal Outgrowth, Cell Migration and GABAergic Differentiation Properties between the Dorsal and Lateral Cortex.

机译：背侧皮质和外侧皮质之间的轴突生长，细胞迁移和GABA能分化特性的早期差异。

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摘要

The regionalization of the cerebral cortex proceeds gradually from early embryonic stages under the control of transcription factors that are expressed in gradients. Two phases can be distinguished at the beginning of cortical development: the genesis of a precocious and transient structure, the preplate, which is followed by development of the cortical plate within the preplate. Cellular indices of early regionalization have not yet been described either in the preplate or in the early cortical plate. In the present study, we identify two regions, lateral and dorsal, in the mouse cortex embryo, which differ strongly in the functional properties of their early neurons. By using culture experiments and grafts on organotypic slices, we show that the earliest neurons in the dorsal cortex extend axons before and more rapidly than the earliest neurons in the lateral cortex. In contrast to the lateral cortex, the dorsal cortex differentiates neurons migrating along axons in vitro. These cells express markersof the GABAergic lineage. Early differences between the two regions suggest that the dorsal part of the cortex generates early neurons with particular intrinsic properties that may in turn specifically influence the later development of the cortical plate in this domain.
机译：在梯度表达的转录因子的控制下，大脑皮质的区域化从胚胎早期开始逐渐进行。在皮层发育的开始阶段可以分为两个阶段：一个是早熟和短暂的结构，即预板的形成，然后是皮层板在预板内的发育。在前板或早期皮质板中尚未描述早期区域化的细胞指数。在本研究中，我们在小鼠皮层胚胎中确定了两个区域，即外侧区域和背面区域，它们的早期神经元的功能特性差异很大。通过使用培养实验和器官型切片上的移植物，我们显示背侧皮层中最早的神经元比外侧皮层中最早的神经元更早且更快速地延伸轴突。与外侧皮层相反，背侧皮层可区分在体外沿轴突迁移的神经元。这些细胞表达GABA能谱系的标志物。这两个区域之间的早期差异表明，皮质的背侧部分会产生具有特定内在特性的早期神经元，而这些固有特性又可能会专门影响此区域中皮质板的后期发育。

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