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首页> 外文期刊>Seminars in cell and developmental biology >Potential roles for RUNX1 and its orthologs in determining hematopoietic cell fate
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Potential roles for RUNX1 and its orthologs in determining hematopoietic cell fate

机译：RUNX1及其直系同源物在确定造血细胞命运中的潜在作用

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摘要

Runxl (also known as AML1, Cbfa2 and Pebpa2b) and Cbfb encode a DNA-binding α subunit and the non-DNA-binding β subunit of a mammalian core-binding factor (CBF). The discovery of RUNX1 and CBFB as genes rearranged in human leukemias prompted predictions that both genes would play important roles in normal hematopoiesis. These predictions were borne out, as indeed Runxl and its Xenopus and Drosophila homologs, Xaml and lozenge (lz). appear to determine hematopoietic cell fate during development. We will review what is known about Runxl function in hematopoiesis in three model organisms, mouse, frog and fly, focusing on the earliest events of hematopoietic cell emergence in the embryo.
机译：Runxl（也称为AML1，Cbfa2和Pebpa2b）和Cbfb编码哺乳动物核心结合因子（CBF）的DNA结合α亚基和非DNA结合β亚基。 RUNX1和CBFB作为人类白血病中重排的基因的发现，促使人们预测这两个基因在正常的造血过程中将起重要作用。这些预言得到了证实，如Runxl及其Xenopus和果蝇的同系物Xaml和锭剂（lz）。似乎决定了发育过程中造血细胞的命运。我们将回顾关于Runxl在三种模型生物（小鼠，青蛙和果蝇）中的造血功能的已知知识，重点是胚胎中造血细胞出现的最早事件。

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