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首页> 外文期刊>Seminars in cell and developmental biology >Mitochondria in early mammalian development
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Mitochondria in early mammalian development

机译：线粒体在哺乳动物早期发育中

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摘要

The role of mitochondria as central determinants of development competence of oocytes and preimplantation stage embryos is considered in the context of the diverse activities these organelles have in normal cell function. Stage- and cell-cycle-specific mitochondrial translocations and redistributions are described with respect to mechanisms of cytoplasmic remodeling that may establish domains of autonomous regulation of mitochondrial function and activity during early development. The functions of mitochondria as intracellular signaling elements, as regulators of signaling pathways, and oxygen sensors in differentiated cells are suggested to have similar capacities during mammalian oogenesis and early embryogenesis. Questions concerning the numerical size of the oocyte mitochondrial complement, the energy required to support normal preovulatory oogenesis and preimplantation embryogenesis, and the regulation of mitochondrial activity by extrinsic and intrinsic factors are addressed with respect the potential they may have for new investigational approaches to study the origin of the differential developmental competence of human oocytes and preimplantation stage embryos.
机译：线粒体作为卵母细胞和着床前阶段胚胎发育能力的中心决定因素，在这些细胞器在正常细胞功能中具有多种活性的背景下被考虑。关于细胞质重塑的机制描述了阶段和细胞周期特异性线粒体易位和重新分布，这些机制可能在早期发育过程中建立了自主调节线粒体功能和活性的域。线粒体作为细胞内信号传导元件，信号传导通路的调节剂以及分化细胞中的氧传感器的功能被认为在哺乳动物卵子发生和早期胚胎发生过程中具有相似的能力。有关卵母细胞线粒体补体的数量大小，支持正常排卵前卵子发生和植入前胚胎发生所需的能量以及外部和内在因素对线粒体活性的调节等问题，这些问题涉及它们可能具有的研究新的研究方法的潜力。人卵母细胞和着床前胚胎发育能力差异的起源。

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