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Molecular Diagnosis of Infection-Related Cancers in Dermatopathology

机译:皮肤病理学中与感染有关的癌症的分子诊断

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摘要

The association between viruses and skin cancer is increasingly recognized in a number of neoplasms, that is, cutaneous squamous cell carcinoma, Kaposi sarcoma, nasopharyngeal carcinoma, and Merkel cell carcinoma, as well as hematolymphoid malignancies such as adult T-cell leukemia/lymphoma and NK/T-cell lymphoma (nasal type) and post-transplant lymphoproliferative disorders. Molecular assays are increasingly used to diagnose and manage these diseases. In this review, molecular features of tumor viruses and related host responses are explored. The tests used to identify such features are summarized. Evaluation of the utility of these assays for diagnosis and/or management of specific tumor types is presented.
机译:病毒和皮肤癌之间的联系在许多肿瘤中得到越来越多的认识,这些肿瘤是皮肤鳞状细胞癌,卡波西肉瘤,鼻咽癌和默克尔细胞癌,以及血淋巴恶性肿瘤,例如成人T细胞白血病/淋巴瘤和NK / T细胞淋巴瘤(鼻型)和移植后淋巴增生性疾病。分子测定法越来越多地用于诊断和管理这些疾病。在这篇综述中,探讨了肿瘤病毒的分子特征和相关的宿主反应。总结了用于识别此类功能的测试。介绍了这些测定法对特定肿瘤类型的诊断和/或治疗的实用性评估。

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