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首页> 外文期刊>Seminars in Gastrointestinal Disease >Immunosuppressive drugs in the treatment of inflammatory bowel disease.
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Immunosuppressive drugs in the treatment of inflammatory bowel disease.

机译：免疫抑制药，用于治疗炎症性肠病。

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Immunosuppressive (IS) drugs are an important option in the management of both forms of inflammatory bowel disease (IBD): Crohn's disease and ulcerative colitis. As the experience of using these agents in the treatment of IBD has increased and more data have become available on their efficacy, these drugs are being used more extensively. The principle drugs used in clinical practice at this time include: azathioprine (AZA) and its metabolite 6-mercaptopurine (6-MP), methotrexate, and cyclosporin A. AZA and 6-MP are generally considered the first line immunosuppressive agents. These drugs are effective and generally well tolerated by the majority of patients started on them, enabling many patients to avoid the predictable side effects of steroid therapy. Because of their extensive use, it is important that clinicians involved in the care of IBD patients are familiar with the IS drugs used to treat IBD, especially AZA and 6-MP.
机译：免疫抑制（IS）药物是治疗两种形式的炎症性肠病（IBD）：克罗恩病和溃疡性结肠炎的重要选择。随着在IBD的治疗中使用这些药物的经验增加以及关于其功效的更多数据可用，这些药物正在被更广泛地使用。目前在临床实践中使用的主要药物包括：硫唑嘌呤（AZA）及其代谢物6-巯基嘌呤（6-MP），甲氨蝶呤和环孢菌素A。AZA和6-MP通常被认为是一线免疫抑制剂。这些药物是有效的，并且大多数开始使用这些药物的患者通常都能很好地耐受，使许多患者避免了类固醇疗法可预测的副作用。由于其用途广泛，因此重要的是，参与IBD患者护理的临床医生必须熟悉用于治疗IBD的IS药物，尤其是AZA和6-MP。

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