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Overview of chronic diarrhea caused by functional neuroendocrine neoplasms.

机译:功能性神经内分泌肿瘤引起的慢性腹泻概述。

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摘要

Eight different neoplastic disorders can cause chronic diarrhea attributable to humoral-mediated diarrhea. These include pancreatic endocrine tumor (PET) syndromes (gastrinomas, VIPomas, glucagonomas, somatostatinomas, PET's releasing calcitonin), carcinoid syndrome, medullary thyroid cancer, and systemic mastocytosis. Because these disorders are an uncommon cause of all chronic diarrheas (<1%), they are not often considered in the differential diagnosis, leading to a delay in diagnosis. This is problematic not only because all are treatable, but also because the neoplasm is frequently malignant. In this article, the characteristics and pathogenesis of the diarrhea, important clinical and diagnostic laboratory features, and treatment of each disorder are briefly reviewed, with an emphasis on recent insights.
机译:八种不同的赘生性疾病可导致慢性腹泻,可归因于体液介导的腹泻。这些包括胰腺内分泌肿瘤(PET)综合征(胃泌素瘤,VIPomas,胰高血糖素瘤,生长抑素瘤,PET释放降钙素),类癌综合征,甲状腺髓样癌和全身肥大细胞增多症。由于这些疾病不是所有慢性腹泻的常见原因(<1%),因此在鉴别诊断中通常不考虑它们,从而导致诊断延迟。这是有问题的,不仅因为所有人都可以治疗,而且因为肿瘤经常是恶性的。在本文中,简要回顾了腹泻的特征和发病机理,重要的临床和诊断实验室特征以及每种疾病的治疗方法,重点是最近的见解。

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