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首页> 外文期刊>Seminars in Gastrointestinal Disease >Clinical evidence for the adenoma-carcinoma sequence, and the management of patients with colorectal adenomas.
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Clinical evidence for the adenoma-carcinoma sequence, and the management of patients with colorectal adenomas.

机译：腺瘤-癌序列和结直肠腺瘤患者治疗的临床证据。

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摘要

A large body of clinical evidence supports the belief that over 95% of colorectal cancers arise in benign adenomatous polyps that develop and grow very slowly over many years. Interruption of the adenoma-carcinoma sequence by resecting adenomatous polyps is a powerful method of secondary prevention of colorectal cancer. Colonoscopy is the procedure of choice for the diagnosis and resection of colorectal polyps. Patients who have had colonoscopic resection of adenomas, and in some cases their close relatives, are at increased risk for developing metachronous polyps and cancer and may benefit from follow-up colonoscopic surveillance. This surveillance should be individually tailored to the perceived risk of each case depending on the features of the adenomas removed and other patient factors such as family history. Widespread adoption of current postpolypectomy guideline recommendations is protective and conserves medical resources.
机译：大量的临床证据支持以下观点，即超过95％的结直肠癌是由良性腺瘤性息肉引起的，良性腺瘤性息肉在多年内发展和生长非常缓慢。通过切除腺瘤性息肉来中断腺瘤-癌序列是二级预防结直肠癌的有效方法。结肠镜检查是诊断和切除大肠息肉的首选方法。结肠镜切除腺瘤的患者，在某些情况下是其近亲，罹患异时息肉和癌症的风险增加，并且可能会从结肠镜随访中受益。应当根据切除的腺瘤的特征和其他患者因素（例如家族史），针对每种情况的感知风险，对监视进行个性化调整。当前息肉切除术后指南建议的广泛采用具有保护性，并节省了医疗资源。

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