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首页> 外文期刊>Seminars in Gastrointestinal Disease >Flat neoplasms in the adenoma-carcinoma sequence in Japan.
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Flat neoplasms in the adenoma-carcinoma sequence in Japan.

机译：日本腺瘤-癌序列中的扁平肿瘤。

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摘要

Flat adenomas have a higher risk of association with adenocarcinoma than the protruded type, and flat cancer has a tendency to invade deeply despite its small size. Furthermore, it has been suggested that flat, small carcinomas readily invade through the muscularis mucosa into the submucosa and are associated with an increased risk of early metastasis into lymph nodes, as compared with polypoid growth pattern cancers. It has become evident that these lesions are becoming more common in Japan, as well as in some western countries. It has been generally believed that the colon is comparable to the stomach in terms of endoscopic diagnostic capability and accuracy. Therefore, we were surprised to learn that flat neoplasms, including flat or depressed adenomas and cancers, exist in the colon, as they seem to have previously been overlooked. Recent significant advances in endoscopic resolution and the development of improved diagnostic techniques and modalities may play an important role in the detection of such lesions. In the present study, the diagnosis and management of such lesions, along with their genetic background, is reviewed. Some techniques for their detection currently being used in Japan will also be reviewed using several actual cases.
机译：扁平腺瘤与突出型癌相比，患腺癌的风险更高，尽管扁平癌的体型较小，但仍倾向于深入侵袭。此外，已经提出，与息肉状生长型癌相比，扁平的小癌容易通过肌层粘膜侵入粘膜下层，并且与早期转移到淋巴结的风险增加有关。显而易见的是，这些病变在日本以及某些西方国家变得越来越普遍。通常认为，就内窥镜诊断能力和准确性而言，结肠可与胃媲美。因此，我们惊讶地发现结肠中存在扁平肿瘤，包括扁平或凹陷的腺瘤和癌症，因为以前似乎忽略了它们。内窥镜分辨率的最新重大进展以及改进的诊断技术和方法的发展可能在检测此类病变中起重要作用。在本研究中，对这些病变的诊断和处理及其遗传背景进行了综述。日本目前正在使用的一些检测技术也将结合实际情况进行审查。

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