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Cholestatic diseases of liver transplantation.

机译:肝移植的胆汁淤积性疾病。

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摘要

Cholestasis is a common finding after liver transplantation and usually signifies graft dysfunction. The most important factor in the evaluation of patients with cholestasis is an awareness of the disorders that commonly arise along a time continuum post-transplant. Therefore, the approach to cholestasis requires a systematic review of biochemical, histological, and radiographic data. This article considers the causes of cholestasis in liver transplant recipients, excluding those associated with biliary anastomotic stricturing. These causes include conditions as diverse as ischemia reperfusion injury, ABO blood group incompatibility, hepatic arterial thrombosis, cytomegalovirus infection, fibrosing cholestatic hepatitis secondary to hepatitis B and C viruses, recurrent primary sclerosing cholangitis, recurrent primary biliary cirrhosis, and chronic rejection. Also examined are management issues pertinent to these conditions and strategies used in preventing or diminishing the effects of cholestasis once established.
机译:胆汁淤积是肝移植后的常见发现,通常表示移植物功能障碍。评估胆汁淤积患者的最重要因素是对通常在移植后连续时间内出现的疾病的认识。因此,胆汁淤积的方法需要对生化,组织学和放射学数据进行系统的审查。本文考虑了肝移植受者胆汁淤积的原因,但与胆道吻合狭窄相关的原因除外。这些原因包括缺血再灌注损伤,ABO血型不相容,肝动脉血栓形成,巨细胞病毒感染,继发于乙型和丙型肝炎病毒的纤维化胆汁淤积性胆汁性肝炎,复发性原发性硬化性胆管炎,复发性原发性胆汁性肝硬化和慢性排斥反应。一旦确定,还应检查与这些情况有关的管理问题以及用于预防或减少胆汁淤积的影响的策略。

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