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首页> 外文期刊>Seminars in Gastrointestinal Disease >The biological impact of Helicobacter pylori colonization.
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The biological impact of Helicobacter pylori colonization.

机译：幽门螺杆菌定植的生物学影响。

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摘要

Helicobacterpylori causes persistent inflammation in the human stomach, yet only a minority of persons harboring this organism develop peptic ulcer disease or gastric malignancy. H. pylori isolates possess substantial phenotypic and genotypic diversity, which may engender differential host inflammatory responses that influence clinical outcome. For example, strains that possess the cag pathogenicity island induce more severe gastritis and augment the risk for developing peptic ulcer disease and distal gastric cancer. However, important geographic differences in susceptibility to disease exist as clear-cut markers for H. pylori strains that affect certain groups of colonized individuals have little or no predictive power for other populations. Recent investigations that have more precisely delineated mechanisms of H. pylori pathogenesis will ultimately help to define which colonized persons bear the highest risk for subsequent development of clinical disease, and thus enable physicians to appropriately focus diagnostic testing and eradication therapy. Although stratification of disease risk based on H. pylori strain characteristics is unlikely to completely account for differences in clinical outcomes, it is an important first step in helping to understand the biology of long-term interactions between H. pylori and its human host.
机译：幽门螺杆菌在人的胃中引起持续的炎症，但是只有少数携带这种生物的人会发展为消化性溃疡病或胃恶性肿瘤。幽门螺杆菌分离物具有实质性的表型和基因型多样性，这可能引起不同的宿主炎症反应，从而影响临床结果。例如，具有cag致病岛的菌株会诱发更严重的胃炎，并增加发生消化性溃疡病和远端胃癌的风险。但是，在疾病易感性方面存在重要的地理差异，因为幽门螺杆菌菌株的明确标记会影响某些群体的定殖个体，而对于其他人群则几乎没有预测能力。具有更精确描述幽门螺杆菌发病机理的最新研究最终将有助于确定哪些定居者对随后的临床疾病发展具有最高风险，从而使医生能够适当关注诊断测试和根除疗法。尽管基于幽门螺杆菌菌株特征的疾病风险分层不可能完全解释临床结果的差异，但这是帮助理解幽门螺杆菌与其人类宿主之间长期相互作用生物学的重要的第一步。

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