Pulmonary pathology.

deMello DE

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Pulmonary pathology.

机译：肺部病理。

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Common causes of neonatal respiratory distress include meconium aspiration, pneumonia, persistent pulmonary hypertension of the newborn, pneumothorax and cystic adenomatoid malformation. Genomics and proteomics have enabled the recent recognition of several additional disorders that lead to neonatal death from respiratory disease. These are broadly classified as disorders of lung homeostasis and have pathological features of proteinosis, interstitial pneumonitis or lipidosis. These pathological changes result from inherited disorders of surfactant proteins or granulocyte-macrophage colony stimulating factor. Abnormal lung vascular development is the basis for another cause of fatal neonatal respiratory distress, alveolar capillary dysplasia with or without associated misalignment of veins. Diagnosis of these genetically transmitted disorders is important because of the serious implications for future siblings. There is also a critical need for establishing an archival tissue bank to permit future molecular biological studies.

机译：新生儿呼吸窘迫的常见原因包括胎粪吸入，肺炎，新生儿持续性肺动脉高压，气胸和囊性腺瘤样畸形。基因组学和蛋白质组学已使最近认识到导致呼吸道疾病新生儿死亡的其他几种疾病。它们被广泛地归类为肺动态平衡障碍，并具有蛋白病，间质性肺炎或脂质变性的病理特征。这些病理变化是由表面活性剂蛋白或粒细胞-巨噬细胞集落刺激因子的遗传性疾病引起的。肺血管异常发育是导致新生儿致命呼吸窘迫，肺泡毛细血管发育不良以及是否伴有静脉错位的另一原因的基础。这些遗传性疾病的诊断很重要，因为对未来的兄弟姐妹有严重的影响。迫切需要建立档案组织库以进行未来的分子生物学研究。

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《Seminars in neonatology: SN》 |2004年第4期|共19页
作者
deMello DE;
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正文语种 eng
中图分类儿科学;
关键词
Neon; Pathology processes; Respiratory distress; Pulmonary lt; 1gt; Lung; 氖; 肺;

机译：Neon;Pathology processes;Respiratory distress;Pulmonary 1;Lung;氖;肺;

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Pulmonary pathology.

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