• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Seizure: the journal of the British Epilepsy Association >Continuous bilateral infusion of GABA in the dorsomedian nucleus of the thalamus elevates the generalized seizure threshold in amygdala-kindled rats.
【24h】

Continuous bilateral infusion of GABA in the dorsomedian nucleus of the thalamus elevates the generalized seizure threshold in amygdala-kindled rats.

机译：丘脑背层核中连续双侧输注GABA升高了杏仁核种大鼠的全身性癫痫发作阈值。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In order to assess the role of continuous intracerebral infusion of GABA over the propagation of generalized seizures from the amygdala, Wistar rats were subjected to a kindling procedure at the left basolateral amygdala. Subsequently, they were implanted with miniosmotic pumps filled with 100mg/mL of GABA in saline, connected to catheters whose tips were placed bilaterally at both dorsomedian nuclei of the thalamus (DMNT). The threshold intensity to provoke local afterdischarges (ADT) and generalized seizures (GST) were measured before, during and after GABA infusion, as well as seizure intensity and signs of ataxia and sedation. While there was no observed variation on ADT, the median GST was significantly increased during, but not after infusion of GABA (P=0.047, compared to the preinfusion value). Seizure intensity was not changed. No signs of neurologic side effects were recorded. These data emphasize the role of DMNT in the generalization of seizures originated at the amygdala.
机译：为了评估连续脑内输注GABA在杏仁核广泛性癫痫发作中的作用，对Wistar大鼠在左侧基底外侧杏仁核进行了点燃程序。随后，将它们植入装有100mg / mL生理盐水中的GABA的微渗透泵，并连接至导管，导管的尖端在两侧均位于丘脑的两体核（DMNT）上。在输注GABA之前，之中和之后，测量引起局部后放电（ADT）和全身性癫痫发作（GST）的阈值强度，以及癫痫发作强度和共济失调和镇静的迹象。尽管未观察到ADT的变化，但在输注GABA期间但未在输注GABA后中值GST显着增加（与输注前的值相比，P = 0.047）。癫痫发作强度没有改变。没有记录到神经系统副作用的迹象。这些数据强调了DMNT在源自杏仁核的癫痫发作泛化中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号