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首页> 外文期刊>Seizure: the journal of the British Epilepsy Association >Phenobarbital withdrawal seizures may occur over several weeks before remitting: Human data and hypothetical mechanism.
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Phenobarbital withdrawal seizures may occur over several weeks before remitting: Human data and hypothetical mechanism.

机译：苯巴比妥戒断发作可能在释放前几周内发生：人类数据和假设机制。

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摘要

This case is the first report of a patient who had phenobarbital (PB) withdrawal seizures after having been seizure-free for 3 years following temporal lobe surgery. The patient had been taking PB for 14 years when a gradual taper of PB was started. When PB was at 60mg/d, a titration of lamotrigine (LTG) was started. However, typical complex seizures occurred when the patient was on PB 60mg/d, along with LTG 25mg/d. PB was increased back to 90mg/d and levetiracetam (LEV) was titrated. Seizures appeared when the patient was on PB 30mg/d and LEV 750mg BID and continued for 3 weeks after PB was stopped and the patient was on LEV 1000mg BID. For the following 6 months, her aura frequency remained elevated in comparison to her baseline aura of two auras per month for the previous year before the start of the PB taper. She was followed for 24 months after her last PB withdrawal seizure. During the last 8 months, her aura frequency returned to her baseline. As suggested by animal studies, the PB withdrawal seizures and increase in aura frequency in this patient may be explained by changes in her levels of GABA(A) receptor subunits.
机译：该病例首次报道了颞叶手术后3年无癫痫发作的苯巴比妥（PB）癫痫发作。开始逐渐逐渐减少PB时，该患者已服用PB 14年。当PB为60mg / d时，开始滴定拉莫三嗪（LTG）。但是，典型的复杂性癫痫发作是在患者服用PB 60mg / d和LTG 25mg / d时发生的。 PB增加至90mg / d，滴定左乙拉西坦（LEV）。当患者接受PB 30mg / d和LEV 750mg BID时出现癫痫发作，并且在PB停止并且患者接受LEV 1000mg BID后持续3周。在接下来的6个月中，与PB锥度开始前一年的每月两个先兆的基线先兆相比，她的先兆频率仍然升高。在她上次PB撤回癫痫发作后随访了24个月。在过去的8个月中，她的先兆频率恢复到基线。正如动物研究表明的那样，该患者的PB抽搐发作和先兆频率增加可以通过其GABA（A）受体亚基水平的变化来解释。

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