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Rising PSAs after primary therapy: active or passive intervention.

机译:初级治疗后PSA升高:主动或被动干预。

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Prostate cancer that has relapsed biochemically after primary therapies, such as prostatectomy or radiation, remains a therapeutic challenge in that no standard treatment option exists for this patient. These patients are often young and may be offered androgen ablation as the mainstay of treatment. Many patients do not wish to undergo a regimen that may be associated with a variety of side effects that will impact on their quality of life. Delaying hormonal treatment in this group does not compromise survival and patients may try a variety of approaches in an attempt to control rising PSAs. Therefore, these patients are an interesting subgroup for whom immunological and alternative therapies may prove to be beneficial. We review new approaches for this population of men, which result in antitumor effects with minimal toxicities.
机译:在主要治疗方法(例如前列腺切除术或放射治疗)后,生化复发的前列腺癌仍然是治疗上的挑战,因为该患者没有标准的治疗选择。这些患者通常很年轻,可能接受雄激素消融作为治疗的主要手段。许多患者不希望接受可能会影响其生活质量的各种副作用的治疗方案。在这一组中延迟激素治疗不会影响生存率,患者可以尝试各种方法来控制升高的PSA。因此,这些患者是一个有趣的亚组,对于他们而言,免疫学和替代疗法可能被证明是有益的。我们审查了针对这种男性人群的新方法,这些方法可产生具有最小毒性的抗肿瘤作用。

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