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首页> 外文期刊>Seminars in Urologic Oncology >Can chemotherapy alter the course of prostate cancer?
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Can chemotherapy alter the course of prostate cancer?

机译：化学疗法可以改变前列腺癌的病程吗？

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摘要

Prostate cancer is perceived to be a disease of older men often diagnosed with widespread metastases that respond to hormonal ablation but for which there are few additional treatment options. Fortunately this perception is rapidly changing as newer combination chemotherapy trials demonstrate improved prostate-specific antigen and measurable response rates and enhanced quality of life. Still, treatment of prostate cancer lags behind treatment of other malignancies. Work remains in understanding the natural history of disease, refining our grouping of patients by stage into clinical trials, and adhering to new response criteria recently developed. Applying the newer active chemotherapy regimens to patients with earlier stage disease should lead to improvements in overall survival.
机译：前列腺癌被认为是老年男性的疾病，通常被诊断为对荷尔蒙消融有反应的广泛转移，但几乎没有其他治疗选择。幸运的是，随着新的联合化疗试验证明改善的前列腺特异性抗原和可测量的应答率以及提高的生活质量，这种看法正在迅速改变。尽管如此，前列腺癌的治疗仍落后于其他恶性肿瘤的治疗。仍然需要了解疾病的自然病史，逐步将我们的患者分组细化为临床试验，并坚持最近开发的新反应标准。对患有早期疾病的患者采用更新的主动化疗方案应可改善总体生存率。

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