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首页> 外文期刊>Seminars in thoracic and cardiovascular surgery >Angiogenesis in non-small cell lung cancer.
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Angiogenesis in non-small cell lung cancer.

机译:非小细胞肺癌的血管生成。

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Two processes are necessary for a tumor colony to grow and become invasive: angiogenesis and basement membrane degradation. Angiogenesis is the formation of new blood vessels from the endothelium of existing vasculature, in response to the metabolic demand of the tumor. Assessment of the degree of tumor angiogenesis may improve risk stratification in patients with lung cancer, especially those with early-stage disease. In addition, the strategy of blocking the mechanism of angiogenesis may prove to be an effective therapeutic alternative for patients with nonsmall cell lung cancer. Clinical trials evaluating novel antiangiogenic agents, including antibodies to vascular endothelial growth factor (VEGF) and compounds directed at the tyrosine kinase receptor, are ongoing.
机译:肿瘤菌落的生长和侵袭需要两个过程:血管生成和基底膜降解。血管生成是响应于肿瘤的代谢需求从现有脉管系统的内皮形成新血管。评估肿瘤血管生成的程度可能会改善肺癌患者的危险分层,尤其是那些患有早期疾病的患者。另外,对于非小细胞肺癌患者,阻断血管生成机制的策略可能被证明是一种有效的治疗选择。正在进行评估新型抗血管生成剂的临床试验,其中包括抗血管内皮生长因子(VEGF)的抗体和针对酪氨酸激酶受体的化合物。

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