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首页> 外文期刊>Seminars in immunopathology >Intravital imaging of anti-tumor immune response and the tumor microenvironment.
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Intravital imaging of anti-tumor immune response and the tumor microenvironment.

机译：活体成像的抗肿瘤免疫反应和肿瘤微环境。

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Tumor growth, invasiveness, and metastasis are dynamic processes involving cancer interactions with the extracellular matrix, the vasculature, and various types of non-cancerous host cells that form the tumor stroma. An often-present stromal component is the immune cells, such as tumor-associated myeloid and lymphocytic infiltrates, yet endogenous anti-tumor immune responses are typically ineffective in tumor rejection and may even contribute to the progression of some cancers. How exactly cancer cells interact with the stroma and invade healthy tissues while avoiding anti-tumor immune responses, and which interactions should be targeted for anti-tumor therapy, can now be studied by minimally invasive observation using multiphoton and other low impact confocal microscopy techniques and fluorescent animal tumor models. Intravital video microscopy has already been instrumental in defining the roles and modes of cellular motility in the angiogenic process and during tissue invasion at the tumor margin. In the hands of cancer immunologists, intravital video microscopy is beginning to unravel the complexity of effector and suppressory lymphocytic interactions in tumors and in the draining lymphoid organs. As the intravital microscopy approach is beginning to move beyond fundamental description and into analyzing the molecular underpinnings of cell's dynamics, future technical advances will undoubtedly provide yet deeper insight while stitching together a systems dynamics view of cancer-host interactions that will keep on inspiring cancer researchers and therapists.
机译：肿瘤生长，侵袭性和转移是动态过程，涉及癌症与细胞外基质，脉管系统和各种类型形成肿瘤基质的非癌宿主细胞的相互作用。通常存在的基质成分是免疫细胞，例如肿瘤相关的髓样和淋巴细胞浸润，但内源性抗肿瘤免疫反应通常在肿瘤排斥中无效，甚至可能有助于某些癌症的进展。现在可以通过使用多光子和其他低影响共聚焦显微镜技术的微创观察来研究癌细胞如何与基质相互作用并侵入健康组织，同时避免抗肿瘤免疫反应，以及应该针对哪些相互作用进行抗肿瘤治疗。荧光动物肿瘤模型。活体视频显微术已经在确定细胞运动在血管生成过程中以及在肿瘤边缘的组织侵入过程中的作用和模式中发挥了作用。在癌症免疫学家的手中，活体视频显微镜开始揭示肿瘤和引流性淋巴器官中效应子和抑制性淋巴细胞相互作用的复杂性。随着活体显微镜方法开始超越基本描述并进入分析细胞动力学的分子基础，毫无疑问，未来的技术进步将提供更深入的见解，同时将癌症-宿主相互作用的系统动力学视图组合在一起，这将继续激发研究人员的灵感。和治疗师。

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