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首页> 外文期刊>International Journal for Vitamin and Nutrition Research: Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung >Effect of vitamin C supplementation on oxidative stress and lipid profiles in hemodialysis patients.
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Effect of vitamin C supplementation on oxidative stress and lipid profiles in hemodialysis patients.

机译：补充维生素C对血液透析患者氧化应激和脂质分布的影响。

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Background and aims: The increase in oxidative stress is the main factor in acceleration of atherosclerosis, leading to death in hemodialysis patients. Vitamin C is one of the most important antioxidants that inhibits lipid peroxidation and improves endothelial function. This study aims to assess the effects of vitamin C supplementation on lipid profiles as well as markers of lipid peroxidation among hemodialysis patients. Materials and methods: In this double-blind, randomized, controlled clinical trial, a total of 42 patients were randomly assigned to vitamin C (n=21) or placebo groups (n=21). Patients in the vitamin C group consumed 250 mg vitamin C and those in the placebo group were given placebo every other day for 12 weeks. Fasting blood samples were collected at baseline and at the end of the study to measure serum concentrations of lipid profiles, as well as malondialdehyde (MDA) and vitamin C. Results: After supplementation with vitamin C, serum vitamin C levels increased significantly in the vitamin C group as compared to baseline (p=0.033). There was also a significant difference in serum vitamin C levels between vitamin C and placebo groups (p=0.001). Serum MDA concentrations were marginally decreased in the vitamin C group after taking supplements (p=0.057). A significant difference was also seen in mean MDA changes between vitamin C and placebo groups (p=0.002). There was a significant difference in serum levels of total cholesterol (p=0.005), low-density lipoprotein (LDL-C) (p=0.012), and LDL-C/high-density lipoprotein (HDL-C) ratio (p=0.018) between the two groups; however, serum triglyceride and HDL-C levels were not significantly different between groups. Conclusion: Every other day supplementation with 250 mg vitamin C for 12 weeks increases serum vitamin C, decreases MDA levels, and improves lipid profiles in hemodialysis patients.
机译：背景与目的：氧化应激的增加是动脉粥样硬化加速的主要因素，导致血液透析患者死亡。维生素C是最重要的抗氧化剂之一，可抑制脂质过氧化并改善内皮功能。这项研究旨在评估补充维生素C对血液透析患者的脂质谱以及脂质过氧化标记的影响。材料和方法：在这项双盲，随机，对照的临床试验中，共有42例患者随机分为维生素C组（n = 21）或安慰剂组（n = 21）。维生素C组的患者服用250毫克维生素C，安慰剂组的患者每隔一天接受安慰剂治疗12周。在基线和研究结束时收集空腹血样，以测量血脂水平以及丙二醛（MDA）和维生素C的血清浓度。结果：补充维生素C后，维生素中的血清维生素C水平显着增加与基线相比，C组（p ＝ 0.033）。维生素C和安慰剂组之间的血清维生素C水平也存在显着差异（p = 0.001）。服用补品后，维生素C组的血清MDA浓度略有降低（p = 0.057）。维生素C和安慰剂组之间的平均MDA变化也发现了显着差异（p = 0.002）。血清总胆固醇（p = 0.005），低密度脂蛋白（LDL-C）（p = 0.012）和LDL-C /高密度脂蛋白（HDL-C）的比率（p =两组之间为0.018）;但是，两组之间的血清甘油三酸酯和HDL-C水平无显着差异。结论：每隔一天补充250 mg维生素C，持续12周可增加血液透析患者的血清维生素C，降低MDA水平并改善血脂状况。

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