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Purification and concentration of collagen by charged ultrafiltration membrane of hydrophilic polyacrylonitrile blend

机译：亲水性聚丙烯腈共混物的超滤膜纯化和浓缩胶原蛋白

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摘要

Asymmetric and charged ultrafiltration membranes were prepared from blends with synthesized polyacrylonitrile (PAN) and hydrophilically modified polyacrylonitrile by the classical phase inversion technique in water. As hydrophilically modified polyacrylonitrile was added, the membranes were more hydrophilic and better anti-fouling performance. Collagen extract was separated by the resulted ultrafiltration membranes. The results showed that, compared to the pure PAN ultrafiltration membrane, the blend membrane possessed higher hydrophilicity and better anti-fouling property. Fouling of collagen particles on the blend membranes was able to reduce as the composition of hydrophilic polyacrylonitrile increased. And the resulted membrane can be used to purify and concentrate collagen extract effectively. The pH of the collagen extract and the hydrophilic polyacrylonitrile content in the blend membrane could influence the membrane separation performance during separating the collagen extract.
机译：通过经典的水相转化技术，将合成的聚丙烯腈（PAN）与亲水改性的聚丙烯腈的混合物制成不对称且带电的超滤膜。由于添加了亲水改性聚丙烯腈，该膜具有更大的亲水性和更好的防污性能。胶原蛋白提取物通过形成的超滤膜分离。结果表明，与纯PAN超滤膜相比，共混膜具有更高的亲水性和更好的防污性能。随着亲水性聚丙烯腈组成的增加，共混膜上胶原颗粒的结垢得以减少。所得膜可用于有效地纯化和浓缩胶原蛋白提取物。胶原蛋白提取物的pH和共混膜中亲水性聚丙烯腈的含量会影响分离胶原蛋白提取物时的膜分离性能。

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