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Theoretical analysis of steady state recycling chromatography with solvent removal

机译：去除溶剂的稳态循环色谱的理论分析

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The possibility to enhance the process performance of steady state recycling (SSR) chromatography by removing solvent was investigated in the framework of the equilibrium theory. A method was developed to choose a priori the relevant cut times corresponding to arbitrary purity constraints and to predict the steady state of the process without performing dynamic simulations. The amount of fresh feed introduced per cycle and the injection width were identified as the only free operating parameters. A relationship was derived between the amount of fresh feed and the solvent removal capacity required to achieve the chosen purities. The performance of three different process configurations was analyzed: solvent removal applied to (I) the fresh feed, (II) the recycle fraction, and (HI) their mixture. It was found that solvent removal facilitates treating more fresh feed per cycle than is possible in a conventional SSR process. In addition, it was shown that the three SSR-SR configurations have identical performance with the same operating parameters. In contrast, the configurations differ with respect to the maximum amount of fresh feed that can be processed per cycle, as well as to the range of feasible injection widths. It was shown that SSR with solvent removal can yield higher productivity and lower eluent consumption than an optimized batch chromatography process that employs solvent removal.
机译：在平衡理论的框架内，研究了通过去除溶剂来增强稳态再循环（SSR）色谱法的工艺性能的可能性。开发了一种方法来预先选择与任意纯度限制相对应的相关切割时间，并在不执行动态模拟的情况下预测过程的稳态。每个周期引入的新鲜饲料量和注射宽度被确定为唯一的自由操作参数。在新鲜进料的量与实现所选纯度所需的溶剂去除能力之间建立了关系。分析了三种不同工艺配置的性能：将溶剂去除应用于（I）新鲜进料，（II）循环馏分和（HI）它们的混合物。已经发现，与常规的SSR方法相比，除去溶剂有助于每个循环处理更多的新鲜饲料。此外，还显示了三种SSR-SR配置在相同的操作参数下具有相同的性能。相反，关于每个循环可处理的最大新鲜进料量以及可行的注射宽度范围，配置有所不同。结果表明，与采用溶剂去除的优化分批色谱法相比，采用溶剂去除的SSR可以提高生产率，降低洗脱液消耗。

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