• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Separation and Purification Technology >Department of Applied Chemistry, Chung-Shan Medical University, Taichung 402, Taiwan, ROC
【24h】

Department of Applied Chemistry, Chung-Shan Medical University, Taichung 402, Taiwan, ROC

机译：中山医科大学应用化学系，台湾台中402

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Analysis of the reaction equilibrium and mass transfer in the extraction of penicillin G (Pen G) into an organic phase is an important research area to develop a cost-effective process for its separation from an aqueous fermentation media. In order to evaluate this, equilibrium experiments were first carried out to select the organic phase (composed of the carrier and solvent) that gives good values for the distribution of penicillin G between the aqueous and organic phases. An organic phase of Amberlite LA-2 in any of the solvents (Shellsol TK/butyl acetate/tributyl phosphate) gave high distribution coefficient and the stoichiometry of the reaction has been shown to follow a simple ratio of 2:2. The performance of the organic phases was evaluated in a membrane contactor and very high percentage extraction was achieved. The extraction was performed by contacting a "feed" solution containing penicillin G (flowing in the fiber side) with an "organic phase" of Amberlite LA-2 in one of the solvents (flowing on the shell side) of the contactor. The antibiotic solutes formed complex with the Amberlite LA-2 molecules which were transported across the fiber wall to the shell side and extracted in the organic phase. The extraction in once-through mode was low and the feed/organic solutions need to be recycled to increase the percentage extraction. In the recycle mode operated at flow rates of 3.6-4.4 mL/s, an extraction of 90-98% was achieved. A simple mathematical model and its semi-analytical solution presented here can be used to determine the overall mass transfer coefficient using the experimental values of the distribution coefficient, operating parameters and the dimensions of the membrane module.
机译：将青霉素G（Pen G）萃取到有机相中时，反应平衡和传质的分析是开发从水发酵培养基中分离出来的经济高效方法的重要研究领域。为了对此进行评估，首先进行平衡实验以选择有机相（由载体和溶剂组成），该有机相为青霉素G在水相和有机相之间的分布提供了良好的值。在任何一种溶剂（Shellsol TK /乙酸丁酯/磷酸三丁酯）中，Amberlite LA-2的有机相均具有较高的分配系数，并且该反应的化学计量比显示为简单的2：2。在膜接触器中评估了有机相的性能，并实现了很高的萃取率。通过使包含青霉素G的“进料”溶液（在纤维侧流动）与Amberlite LA-2的“有机相”在接触器的一种溶剂（在壳侧流动）中进行萃取。抗生素溶质与Amberlite LA-2分子形成复合物，该分子通过纤维壁转运到壳侧并在有机相中提取。直通模式下的萃取率低，进料/有机溶液需要循环使用以提高萃取率。在以3.6-4.4 mL / s的流速运行的循环模式下，提取率达到90-98％。此处介绍的简单数学模型及其半解析解可用于通过分配系数，操作参数和膜组件尺寸的实验值确定整体传质系数。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号