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首页> 外文期刊>Separation and Purification Technology >Isolation and analysis of bioactive isoflavonoids and chalcone from a new type of Brazilian propolis
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Isolation and analysis of bioactive isoflavonoids and chalcone from a new type of Brazilian propolis

机译：新型巴西蜂胶中生物活性异黄酮和查尔酮的分离与分析

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摘要

Activity-directed fractionation and purification processes were employed to identify isoflavonoids with antioxidant and antimicrobial activities from Brazilian red propolis. Crude propolis was extracted with ethanol (80%, v/v) and fractioned by liquid-liquid extraction technique using hexane and chloroform. Since chloroform fraction showed strong antioxidant and antimicrobial activities it was purified and isolated using various chromatographic techniques. Comparing our spectral data (UV, NMR, and mass spectrometry) with values found in the literature, we identified two bioactive isoflavonoids (vestitol and neovestitol), together with one chalcone (isoliquiritigenin). Vestitol presented higher antioxidant activity against fl-carotene consumption than neovestitol. The antimicrobial activity of these three compounds against Staphylococcus aureus, Streptococcus mutans, and Actinomyces naeslundii was evaluated and we concluded that isoliquiritigenin was the most active one with lower MIC, ranging from 15.6 to 62.5 μg/mL Our results showed that Brazilian red propolis has biologically active isoflavonoids that may be used as a mild antioxidant and antimicrobial for food preservation.
机译：采用活性导向的分离和纯化方法从巴西红蜂胶中鉴定具有抗氧化和抗菌活性的异黄酮。用乙醇（80％，v / v）萃取蜂胶粗品，并使用己烷和氯仿通过液-液萃取技术进行分馏。由于氯仿馏分显示出强大的抗氧化和抗菌活性，因此使用各种色谱技术对其进行纯化和分离。将我们的光谱数据（UV，NMR和质谱）与文献中的值进行比较，我们发现了两种具有生物活性的异黄酮类化合物（vestitol和neovestitol），以及一种查尔酮（isoquiquiritigenin）。雌二醇对氟-胡萝卜素消耗的抗氧化活性高于新戊醇。评估了这三种化合物对金黄色葡萄球菌，变形链球菌和内生放线菌的抗菌活性，我们得出结论，异黄体生成素是最活跃的，MIC较低，范围从15.6至62.5μg/ mL。我们的结果表明，巴西红蜂胶具有生物学活性。活性异黄酮可用作食品防腐剂的温和抗氧化剂和抗菌剂。

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