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首页> 外文期刊>Separation and Purification Technology >Separation and purification of two isomorphic steroids by a novel extractive drowning out crystallization
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Separation and purification of two isomorphic steroids by a novel extractive drowning out crystallization

机译：一种新型浸没结晶的分离纯化两种同构类固醇

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摘要

A novel extraction drowning out crystallization technology was brought forward for separation and purification of two isomorphic steroid pharmaceutical intermediates.In this process,extraction and crystallization are conducted in the same crystallizer simultaneously.The two immiscible (partial miscible) liquid phases were achieved by adding water into the toluene-DMF system.The role played by water is both as an antisolvent for a crystallization and a trigger to generate two immiscible phases for extraction.The advantage of this method is that two relative pure product can be achieved in a crystallization process.The experimental result shows a good prospect of this method for industrial separation of the studied two isomorphic steroids.
机译：提出了一种新的浸出淹没结晶技术，用于分离和纯化两种同构类固醇药物中间体。在此过程中，在同一结晶器中同时进行萃取和结晶。通过加水获得两种不混溶（部分混溶）的液相。水的作用既是结晶的反溶剂，也是引发生成两个不混溶相进行萃取的触发器，这种方法的优点是在结晶过程中可以得到两个相对纯的产物。实验结果表明该方法可用于工业分离所研究的两种同构类固醇。

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