• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Separation and Purification Technology >Preparative separation and purification of rosavin in Rhodiola rosea by macroporous adsorption resins
【24h】

Preparative separation and purification of rosavin in Rhodiola rosea by macroporous adsorption resins

机译：大孔吸附树脂对玫瑰红景天中罗沙芬的制备及分离纯化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Rosavin is one of the main bioactive components in Rhodiola rosea L with known pharmacological effects. In this study, a simple method for preparative separation and purification of rosavin from R. rosea L was developed with macroporous adsorption resins. The adsorption isotherms and desorption performances of some resins have been determined and compared. Depending on its hydrophobic force, HPD-200 resin, a styrene-divinylbenzene (SDVB) copolymer, offers the best adsorption and desorption properties for rosavin based on the research results, its adsorption data fit best to the Langmuir adsorption model. Dynamic adsorption and desorption was performed on HPD-200 resin packed in a glass column to obtain optimal parameters for the separation of rosavin. The optimum conditions were as follow. The volume, concentration, bed height and flow rate of loading sample were 4 bed volumes (BV), 0.24 mg/mL, 30 cm and 2 BV/h, respectively, at 25 °C; desorption was performed successively with 30% ethanol of 4 bed volumes, 40% ethanol of 2.5 bed volumes and 60% ethanol of 3 bed volumes. After one run treatment with HPD-200, the rosavin content in the product was increased from 0.69% to 11.02% with a recovery of 82.46%. In this case, the process throughout is 1.34grosavin/Ladsorbent/day, solvent usage is 7.14 L ethanol/g rosavin. The simple purification scheme avoids toxic organic solvent and thus, increases the safety of the process with a potential industrial application prospect
机译：罗莎芬是玫瑰红景天中的主要生物活性成分之一，具有已知的药理作用。在这项研究中，使用大孔吸附树脂开发了一种简单的方法，用于从玫瑰蔷薇中分离制备和纯化玫瑰香素。已经确定并比较了某些树脂的吸附等温线和解吸性能。根据其研究结果，苯乙烯-二乙烯基苯（SDVB）共聚物HPD-200树脂根据其疏水力可为罗萨文提供最佳的吸附和解吸性能，其吸附数据最适合Langmuir吸附模型。对填充在玻璃柱中的HPD-200树脂进行动态吸附和解吸，以获得用于分离罗莎文的最佳参数。最佳条件如下。在25°C下，上样样品的体积，浓度，床高和流速分别为4个床体积（BV），0.24 mg / mL，30 cm和2 BV / h;依次用4床体积的30％乙醇，2.5床体积的40％乙醇和3床体积的60％乙醇进行解吸。用HPD-200进行一次运行处理后，产品中的罗莎芬含量从0.69％增加到11.02％，回收率达到82.46％。在这种情况下，整个过程为1.34grosavin / Ladsorbent / day，溶剂用量为7.14 L乙醇/ g rosavin。简单的纯化方案避免了有毒的有机溶剂，因此增加了工艺的安全性，具有潜在的工业应用前景

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号