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首页> 外文期刊>Separation and Purification Technology >Purification of nanoparticle suspensions by a concentration/diafiltration process
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Purification of nanoparticle suspensions by a concentration/diafiltration process

机译：通过浓缩/渗滤工艺纯化纳米颗粒悬浮液

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摘要

Nanoparticles are solid colloidal particles ranging in size from about 10-1000nm.Depending on the method of preparation,the following potentially toxic impurities can be present in the nanoparticulate suspensions: organic solvents,surfactants,residual monomers,polymerization initiators and large polymer aggregates.The potential use of nanoparticles in an oral or parenteral route implies an intensive purification.In the present work,we investigated the purification by crossflow microfiltration of nanoparticulate suspensions prepared by an emulsion-diffusion technique.The purification process involved two steps,first a concentration step where the preparation is concentrated by a factor of 1/5,then a diafiltration step,where the feed volume is kept constant by adding continuously pure water.It was shown that polyvinyl alcohol(PVAL)and ethyl acetate concentrations decreased to an acceptable level,after 40 min of concentration and 2 h of diafiltration.The nanoparticulate suspension remained stable after 9 weeks of storage.Indomethacin loaded nanocapsules were purified without loss of drug efficiency.Also,the influence of process parameters as crossflow flowrate on the PVAL amount present in the feed was investigated.
机译：纳米粒子是固体胶体粒子，大小约为10-1000nm。根据制备方法的不同，纳米粒子悬浮液中可能存在以下潜在有毒杂质：有机溶剂，表面活性剂，残留单体，聚合引发剂和大的聚合物聚集体。纳米颗粒在口服或非肠道途径中的潜在用途意味着需要大量纯化。在本工作中，我们研究了通过乳液扩散技术制备的纳米颗粒悬浮液的交叉流微滤纯化。纯化过程涉及两个步骤，首先是浓缩步骤，其中将制剂浓缩至原来的1/5，然后进行渗滤步骤，在该步骤中，通过连续添加纯净水使进料量保持恒定。结果表明，聚乙烯醇（PVAL）和乙酸乙酯的浓度在降低至可接受水平后浓缩40分钟，渗滤2小时。残留纳米颗粒贮存9周后保持稳定。纯化了载有吲哚美辛的纳米胶囊，而没有损失药物的效率。此外，还研究了工艺参数（如横流流速）对饲料中PVAL含量的影响。

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