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首页> 外文期刊>Seminars in cancer biology >Chemokine signaling in cancer: one hump or two?
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Chemokine signaling in cancer: one hump or two?

机译：癌症中的趋化因子信号传导：一两个驼峰？

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Chemokines and their receptors play essential roles in the development and function of multiple tissues. Chemokine expression, particularly CXCL12 and its receptor CXCR4, has prognostic significance in several cancers apparently due to chemokine mediated growth and metastatic spread. These observations provide the rationale for pursuing CXCR4 inhibition for cancer chemotherapy. However, the multiple homeostatic functions of CXCR4 may preclude global inhibition as a therapeutic strategy. Here I review CXCR4 signaling and how it might differ in normal and transformed cells with special emphasis on the role that altered CXCR4 counter-regulation might play in tumor biology. I propose that CXCR4 mediates unique signals in cancer cells as a consequence of abnormal counter-regulation and that this results in novel biological responses. The importance of testing this hypothesis lies in the possibility that targeting abnormal CXCR4 signaling might provide an anti-tumor effect without disturbing normal CXCR4 functions.
机译：趋化因子及其受体在多种组织的发育和功能中起重要作用。趋化因子表达，特别是CXCL12及其受体CXCR4，显然是由于趋化因子介导的生长和转移扩散而在多种癌症中具有预后意义。这些观察结果为癌症化疗追求CXCR4抑制提供了理论依据。但是，CXCR4的多种稳态功能可能会排除整体抑制作为一种治疗策略。在这里，我回顾了CXCR4信号传导及其在正常细胞和转化细胞中的不同之处，特别着重指出了改变CXCR4反调节作用在肿瘤生物学中的作用。我提出，由于异常反调节，CXCR4在癌细胞中介导了独特的信号，并且这导致了新的生物学反应。测试该假设的重要性在于，针对异常CXCR4信号转导可能会在不干扰正常CXCR4功能的情况下提供抗肿瘤作用。

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