Polyoma virus and simian virus 40 as cancer models: history and perspectives.

Atkin SJ; Griffin BE; Dilworth SM

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Polyoma virus and simian virus 40 as cancer models: history and perspectives.

机译：多瘤病毒和猿猴病毒40作为癌症模型：历史和观点。

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Polyoma virus and SV40 are the founding members of the Polyomaviridae. They are small viruses, with a genome consisting of around 5.3kbases of closed circular, double-stranded DNA. This simplicity, the ease with which they can be grown, and their capacity to cause cancers in newborn rodents has made them popular models for studying the molecular basis of cancer formation. As a consequence, many of the underlying principles involved in tumorigenesis have been uncovered during the study of these viruses. For instance, the discovery of p53, Rb protein function, tyrosine kinases and PI3 kinases were all made when examining polyoma virus and SV40. Here we review how these discoveries were made, and the influence they have had on our understanding of cancer development.

机译：Polyoma病毒和SV40是Polyomaviridae的创始成员。它们是小型病毒，其基因组由约5.3kbases的闭合环状双链DNA组成。这种简单性，它们易于生长以及在新生啮齿动物中引起癌症的能力使它们成为研究癌症形成的分子基础的流行模型。结果，在研究这些病毒的过程中发现了许多与肿瘤发生有关的基本原理。例如，在检查多瘤病毒和SV40时发现了p53，Rb蛋白功能，酪氨酸激酶和PI3激酶。在这里，我们回顾了这些发现是如何产生的，以及它们对我们对癌症发展了解的影响。

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《Seminars in cancer biology》 |2009年第4期|共7页
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Atkin SJ; Griffin BE; Dilworth SM;
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1. Polyoma virus and simian virus 40 as cancer models: history and perspectives. [J] . Atkin SJ, Griffin BE, Dilworth SM Seminars in cancer biology . 2009,第4期

机译：多瘤病毒和猿猴病毒40作为癌症模型：历史和观点。
2. Loss of Polyoma Virus Infectivity as a Result of a Single Amino Acid Change in a Region of Polyoma Virus Large T-Antigen Which Has Extensive Amino Acid Homology with Simian Virus 40 Large T-Antigen [J] . Adrian C. Hayday, Furzana Chaudry, Mike Fried Journal of Virology . 1983,第2期

机译：由于单一的氨基酸变化在多群病毒大型T-抗原区域中的单一氨基酸变化，具有与Simian病毒40大T-抗原的氨基酸同源性的单一氨基酸变化导致多膜病毒感染性。
3. Loss of Polyoma Virus Infectivity as a Result of a Single Amino Acid Change in a Region of Polyoma Virus Large T-Antigen Which Has Extensive Amino Acid Homology with Simian Virus 40 Large T-Antigen [J] . Adrian C. Hayday, Furzana Chaudry, Mike Fried Journal of Virology . 1983,第2期

机译：由于单一的氨基酸变化在多群病毒大型T-抗原区域中的单一氨基酸变化，具有与Simian病毒40大T-抗原的氨基酸同源性的单一氨基酸变化导致多膜病毒感染性。
4. Computational Analysis of Nucleosome Positioning Signals in the Simian Virus 40 Chromatin [C] . Hongyan Zhao, Hong Yan International MultiConference of Engineers and Computer Scientists . 2009

机译：亚麻病毒40染色质中核心定位信号的计算分析
5. The association between the polyomaviruses, JC virus, Bk virus, and simian virus 40, and human brain tumors. [D] . Rollison, Dana Elise Maher. 2003

机译：多瘤病毒，JC病毒，Bk病毒和猿猴病毒40与人脑肿瘤之间的关联。
6. Loss of Polyoma Virus Infectivity as a Result of a Single Amino Acid Change in a Region of Polyoma Virus Large T-Antigen Which Has Extensive Amino Acid Homology with Simian Virus 40 Large T-Antigen [O] . Adrian C. Hayday, Furzana Chaudry, Mike Fried 1983

机译：多胺病毒大T-抗原区域中单个氨基酸变化导致多瘤病毒感染力丧失该区域与猿猴病毒具有广泛的氨基酸同源性40大T-抗原
7. The JC and BK human polyoma viruses appear to be recent introductions to some South American Indian tribes: There is no serological evidence of cross-reactivity with the simian polyoma virus SV40 [O] . Major, Eugene O., Neel, James V. 1998

机译：JC和BK人多瘤病毒似乎是一些南美印第安部落的最新介绍：没有血清学证据表明与猿猴多瘤病毒SV40有交叉反应

Polyoma virus and simian virus 40 as cancer models: history and perspectives.

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