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首页> 外文期刊>Seminars in cancer biology >Cancer as a reprogramming-like disease: implications in tumor development and treatment.
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Cancer as a reprogramming-like disease: implications in tumor development and treatment.

机译：作为重编程样疾病的癌症：对肿瘤发展和治疗的影响。

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摘要

Cancer is a clonal malignant disease originated in a single cell and characterized by the accumulation of partially differentiated cells that are phenotypically reminiscent of normal stages of differentiation. Given the fact that human cancer is diagnosed at later stages and cannot be monitored during its natural evolution, the origin of tumors has been a subject of continuing discussion. Animal models provide a means to determine the identity of the cell-of-origin leading to malignancy and to develop new treatments. Recent findings in mice have shown that cancer stem cells could arise through a reprogramming-like mechanism, suggesting that genetic lesions that initiate the cancer process might be dispensable for tumor progression and maintenance. This review addresses the impact of these results toward a better understanding of carcinogenesis and proposes research avenues for tackling these issues in the future.
机译：癌症是一种起源于单个细胞的克隆性恶性疾病，其特征在于表型上让人联想到正常分化阶段的部分分化细胞的积累。鉴于人类癌症是在较晚的阶段被诊断出来并且在其自然进化过程中无法监测的事实，因此肿瘤的起源一直是不断讨论的话题。动物模型提供了一种确定导致恶性肿瘤的起源细胞的身份并开发新疗法的方法。小鼠的最新发现表明，癌症干细胞可能通过类似重编程的机制产生，这表明引发癌症过程的遗传损伤可能对于肿瘤的进展和维持是必不可少的。这篇综述探讨了这些结果对更好地了解致癌作用的影响，并提出了今后解决这些问题的研究途径。

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