Oncogenic Ras and its role in tumor cell invasion and metastasis.

Campbell PM; Der CJ

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Oncogenic Ras and its role in tumor cell invasion and metastasis.

机译：致癌Ras及其在肿瘤细胞侵袭和转移中的作用。

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The processes by which cancer cells leave the tumor and enter adjacent tissue is known as invasion, whereas metastasis refers to secondary tumor colonization of tissue at a distance from the primary lesion. These two events are the most lethal of cancer phenomena and the signaling mechanisms that govern them are complex. The Ras signaling pathways are well represented in their involvement in tumor initiation, but considerably less is known about their contribution to invasion and metastasis. In this review, we discuss the current evidence for mutant Ras proteins as significant players in these aspects of cancer progression.

机译：癌细胞离开肿瘤并进入相邻组织的过程称为侵袭，而转移是指继发于原发病变部位的组织继发性肿瘤定植。这两个事件是最致命的癌症现象，控制它们的信号传导机制很复杂。 Ras信号通路在其参与肿瘤起始方面得到了很好的体现，但对它们对侵袭和转移的贡献知之甚少。在这篇综述中，我们讨论了突变Ras蛋白作为癌症进展这些方面的重要参与者的当前证据。

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《Seminars in cancer biology》 |2004年第2期|共10页
作者
Campbell PM; Der CJ;
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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Neoplasm Invasiveness; Neoplasm Metastasis; Oncogene Protein p21(ras); 肿瘤侵润; 肿瘤转移; 癌基因蛋白质P21(RAS);

机译：Neoplasm Invasiveness;Neoplasm Metastasis;Oncogene Protein p21(ras);肿瘤侵润;肿瘤转移;癌基因蛋白质P21(RAS);

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1. Oncogenic Ras and its role in tumor cell invasion and metastasis. [J] . Campbell PM, Der CJ Seminars in cancer biology . 2004,第2期

机译：致癌Ras及其在肿瘤细胞侵袭和转移中的作用。
2. Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis. [J] . Lemieux E, Bergeron S, Durand International Journal of Cancer =: Journal International du Cancer . 2009,第7期

机译：组成型活性MEK1足以在肠上皮细胞中诱导上皮向间充质转化，并促进肿瘤的侵袭和转移。
3. Roles of membrane-type matrix metalloproteinase-1 in tumor invasion and metastasis. [J] . Sato H, Takino T, Miyamori H Cancer science. . 2005,第4期

机译：膜型基质金属蛋白酶-1在肿瘤侵袭和转移中的作用。
4. Photodynamic therapy stimulates anti-tumor immune response in mouse models: the role of regulatory T-cells, anti-tumor antibodies, and immune attack on brain metastases [C] . Fatma Vatansever, Masayoshi Kawakubo, Hoon Chung, Biophotonics and immune responses VIII . 2013

机译：光动力疗法在小鼠模型中刺激抗肿瘤免疫反应：调节性T细胞，抗肿瘤抗体的作用以及对脑转移瘤的免疫攻击
5. The role of adhesion proteins in regulating tumor cell invasion and metastasis. [D] . Beaty, Brian T. 2014

机译：粘附蛋白在调节肿瘤细胞侵袭和转移中的作用。
6. Identification a novel tumor-suppressive hsa-miR-599 regulates cells proliferation migration and invasion by targeting oncogenic MYC in hepatocellular carcinoma [O] . Jingjing Tian, Xibao Hu, Wei Gao, 2016

机译：通过靶向肝癌中的致癌性MYC鉴定出一种新型的肿瘤抑制性hsa-miR-599调节细胞增殖迁移和侵袭
7. Dominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and Metastasis. [O] . Hiromitsu Ito, Shinji Tanaka, Yoshimitsu Akiyama, 2016

机译：DCLK1在人胰腺癌干细胞中的显性表达加速肿瘤侵袭和转移。

Oncogenic Ras and its role in tumor cell invasion and metastasis.

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