Notch and T cell malignancy.

Zweidler McKay PA; Pear WS

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Notch and T cell malignancy.

机译：切口和T细胞恶性肿瘤。

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Notch signaling is required for normal T cell development. However, Notch expression must be precisely regulated as constitutive Notch signaling leads to T cell lymphomas. Recent evidence has provided insights into potential mechanisms of Notch-mediated lymphomagenesis and its relationship to T cell development. The evidence suggests that Notch likely interacts with several important cellular pathways and can cooperate with other oncogenes during lymphomagenesis. In particular, Notch appears to modulate pre-TCR signaling, inhibit the E2A pathway, and in murine leukemia models, frequently cooperates with Myc, E2A-PBX and dominant negative Ikaros dysregulation. This review will present current knowledge in these areas and explore theories on Notch-mediated T cell lymphomagenesis.

机译：正常的T细胞发育需要Notch信号传导。但是，Notch表达必须被精确调节，因为组成性Notch信号传导会导致T细胞淋巴瘤。最近的证据提供了对Notch介导的淋巴瘤发生的潜在机制及其与T细胞发育的关系的见解。有证据表明，Notch可能与几种重要的细胞途径相互作用，并且可以在淋巴瘤发生过程中与其他癌基因协同作用。尤其是，Notch似乎可以调节TCR之前的信号传导，抑制E2A途径，在鼠白血病模型中，经常与Myc，E2A-PBX和显性负Ikaros失调协同作用。本文将介绍这些领域的最新知识，并探讨Notch介导的T细胞淋巴瘤发生的理论。

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《Seminars in cancer biology》 |2004年第5期|共12页
作者
Zweidler McKay PA; Pear WS;
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正文语种 eng
中图分类肿瘤学;
关键词
T-Lymphocytes; E2A; development aspects; Malignant Neoplasms; Cellular biology; T淋巴细胞;

机译：T-Lymphocytes;E2A;development aspects;Malignant Neoplasms;Cellular biology;T淋巴细胞;

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1. Notch and T cell malignancy. [J] . Zweidler McKay PA, Pear WS Seminars in cancer biology . 2004,第5期

机译：切口和T细胞恶性肿瘤。
2. Characterization of a High-Molecular-Weight Notch Complex in the Nucleus of Notchic-Transformed RKE Cells and in a Human T-Cell Leukemia Cell Line [J] . Shawn Jeffries, David J. Robbins, Anthony J. Capobianco Molecular and Cellular Biology . 2002,第11期

机译：棘突转化的RKE细胞核和人类T细胞白血病细胞系中的高分子量缺口复合物的表征。
3. Characterization of a High-Molecular-Weight Notch Complex in the Nucleus of Notchic-Transformed RKE Cells and in a Human T-Cell Leukemia Cell Line [J] . Shawn Jeffries, David J. Robbins, Anthony J. Capobianco Molecular and Cellular Biology . 2002,第11期

机译：棘突转化的RKE细胞核和人类T细胞白血病细胞系中的高分子量缺口复合物的表征。
4. Multiscale Static Analysis of Notched and Un-notched Laminates using the Generalized Method of Cells [C] . B. Stier, P. Naghipour, E. J. Pineda, AIAA/ASCE/AHS/ASC structures, structural dynamics and materials conference;AIAA SciTech forum . 2015

机译：使用单元格广义方法的带缺口和无缺口层板的多尺度静态分析
5. Inhibition of ErbB-2 activates Notch-1 through cell surface accumulation of Notch-1 and its ligand, JAG-1 and sensitizes ErbB-2 positive breast cancer cells to a GSI [D] . Patel, Parul 2008

机译：ErbB-2的抑制通过Notch-1及其配体JAG-1的细胞表面积聚来激活Notch-1，并使ErbB-2阳性乳腺癌细胞对GSI敏感
6. Characterization of a High-Molecular-Weight Notch Complex in the Nucleus of Notchic-Transformed RKE Cells and in a Human T-Cell Leukemia Cell Line [O] . Shawn Jeffries, David J. Robbins, Anthony J. Capobianco 2002

机译：刻痕转化的RKE细胞核和人类T细胞白血病细胞系中的高分子量缺口复合物的表征。
7. Characterization of a High-Molecular-Weight Notch Complex in the Nucleus of Notchic-Transformed RKE Cells and in a Human T-Cell Leukemia Cell Line [O] . Jeffries, Shawn, Robbins, David J., Capobianco, Anthony J. 2002

机译：刻痕转化的RKE细胞核和人类T细胞白血病细胞系中的高分子量缺口复合物的表征。

Notch and T cell malignancy.

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