Stress-activated protein kinases-tumor suppressors or tumor initiators?

Engelberg D

首页> 外文期刊>Seminars in cancer biology >Stress-activated protein kinases-tumor suppressors or tumor initiators?

【24h】

Stress-activated protein kinases-tumor suppressors or tumor initiators?

机译：应激激活的蛋白激酶-抑癌剂还是肿瘤引发剂？

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The biology and the pathology of the stress-activated protein kinases (SAPKs; p38s and c-Jun-NH(2)-terminal kinases (JNKs)) are somewhat confusing. In some systems, these enzymes augment cell proliferation whereas in other cells they support growth arrest and tumor suppressing activity. Similarly, in some types of cancer SAPKs' activity is suppressed while in others SAPKs seem to be an essential part of the transformative machinery. Revealing the role of SAPKs in cancer is important for planning an appropriate therapeutic strategy. Here, I describe the data supporting the role of SAPKs as tumor suppressors in some systems and as pro-oncogenic in others. Possible resolutions for the paradox of stress kinases are also discussed.

机译：应力激活蛋白激酶（SAPKs; p38s和c-Jun-NH（2）-末端激酶（JNKs））的生物学和病理学有些令人困惑。在某些系统中，这些酶增强细胞增殖，而在其他细胞中，它们则支持生长停滞和肿瘤抑制活性。同样，在某些类型的癌症中，SAPKs的活性受到抑制，而在另一些类型中，SAPKs似乎是转化机制的重要组成部分。揭示SAPK在癌症中的作用对于规划适当的治疗策略很重要。在这里，我描述了支持SAPK在某些系统中起抑癌作用而在另一些系统中起促癌作用的数据。还讨论了应激激酶悖论的可能解决方案。

著录项

来源
《Seminars in cancer biology》 |2004年第4期|共12页
作者
Engelberg D;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Neoplasms; activate; Protein Kinases; Stress bismuth subsalicylate; 肿瘤; 蛋白激酶类;

机译：Neoplasms;activate;Protein Kinases;Stress bismuth subsalicylate;肿瘤;蛋白激酶类;

相似文献

外文文献
中文文献
专利

1. Stress-activated protein kinases-tumor suppressors or tumor initiators? [J] . Engelberg D Seminars in cancer biology . 2004,第4期

机译：应激激活的蛋白激酶-抑癌剂还是肿瘤引发剂？
2. A dominant mutant allele of the ING4 tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis. [J] . Kim S, Welm AL, Bishop JM Cancer research: The official organ of the American Association for Cancer Research, Inc . 2010,第12期

机译：在人癌细胞中发现的ING4肿瘤抑制器的主要突变等位基因加剧了Myc引发的小鼠乳腺肿瘤瘤。
3. Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-signaling pathway [J] . ChaiJ., HeY., CaiS..-Y., Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2012,第5期

机译：人类阻塞性胆汁淤积症中肝多药耐药相关蛋白3 / ATP结合盒亚家族C 3的表达是通过肿瘤坏死因子α和c-Jun NH2-末端激酶/应激激活的蛋白激酶信号传导途径介导的
4. Clustering Protein-Protein Interaction Network of TP53 Tumor Suppressor Protein using Markov Clustering Algorithm [C] . Thia Sabel Permata, Alhadi Bustamam International Conference on Advanced Computer Science and Information Systems . 2015

机译：使用Markov聚类算法的TP53肿瘤抑制蛋白的聚类蛋白 - 蛋白质相互作用网络
5. Combinatorial Approaches to Study Protein Stability: Design and Application of Cell-Based Screens to Engineer Tumor Suppressor Proteins [D] . Ramasubramanian, Brinda 2011

机译：研究蛋白质稳定性的组合方法：基于细胞的筛查技术设计肿瘤抑制蛋白的应用
6. STEM-24miR-340 ACTS AS A TUMOR SUPPRESSOR IN TUMORIGENESIS OF HUMAN GLIOMA-INITIATING CELLS BY TARGETING TISSUE PLASMINOGEN ACTIVATOR [O] . Daisuke Yamashita, Toru Kondo, Hisaaki Takahashi, 2015

机译：STEM-24miR-340 ACTS靶向组织纤溶酶原激活剂作为肿瘤抑制人胶质瘤起始细胞的肿瘤形成
7. Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14 ▿ § [O] . Asselin-Labat, Marie-Liesse, Sutherland, Kate D., Vaillant, François, 2011

机译：Gata-3负调控乳腺发光祖细胞的肿瘤起始能力，并靶向假定的肿瘤抑制因子Caspase-14。 ▿ §
8. RNA-Binding Proteins as Novel Oncoproteins and Tumor Suppressors in Breast Cancer [R] . Brewer, G. 2006

机译：RNa结合蛋白作为乳腺癌中的新型癌蛋白和肿瘤抑制因子

Stress-activated protein kinases-tumor suppressors or tumor initiators?

摘要

著录项

相似文献

相关主题

期刊订阅