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首页> 外文期刊>Seminars in cancer biology >Cooperation and competition in the dynamics of tissue architecture during homeostasis and tumorigenesis
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Cooperation and competition in the dynamics of tissue architecture during homeostasis and tumorigenesis

机译：稳态与肿瘤发生过程中组织结构动力学的合作与竞争

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摘要

The construction of a network of cell-to-cell contacts makes it possible to characterize the patterns and spatial organization of tissues. Such networks are highly dynamic, depending on the changes of the tissue architecture caused by cell division, death and migration. Local competitive and cooperative cell-to-cell interactions influence the choices cells make. We review the literature on quantitative data of epithelial tissue topology and present a dynamical network model that can be used to explore the evolutionary dynamics of a two dimensional tissue architecture with arbitrary cell-to-cell interactions. In particular, we show that various forms of experimentally observed types of interactions can be modelled using game theory. We discuss a model of cooperative and non-cooperative cell-to-cell communication that can capture the interplay between cellular competition and tissue dynamics. We conclude with an outlook on the possible uses of this approach in modelling tumorigenesis and tissue homeostasis.
机译：细胞间接触网络的构建使得表征组织的模式和空间组织成为可能。这样的网络是高度动态的，取决于由细胞分裂，死亡和迁移引起的组织结构的变化。局部竞争性和合作性的细胞间交互作用会影响细胞的选择。我们回顾了有关上皮组织拓扑结构定量数据的文献，并提出了一种动态网络模型，该模型可用于探索具有任意细胞间相互作用的二维组织结构的演化动力学。特别是，我们表明可以使用博弈论对各种形式的实验观察到的交互类型进行建模。我们讨论了一种合作和非合作的细胞间通信模型，该模型可以捕获细胞竞争与组织动力学之间的相互作用。我们以对这种方法在肿瘤发生和组织动态平衡建模中可能使用的前景作了总结。

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