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首页> 外文期刊>Seminars in cancer biology >The role of chemokines in cancer immune surveillance by the adaptive immune system.
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The role of chemokines in cancer immune surveillance by the adaptive immune system.

机译:趋化因子通过适应性免疫系统在癌症免疫监视中的作用。

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摘要

Chemokines are key molecules involved in the migration and homeostasis of immune cells. However, also tumor cells use chemokine signals for different processes such as tumor progression and metastasis. It is thus unclear whether chemokines, through their immunostimulatory roles, contribute to the repression of tumor cells by tumor immunosurveillance or whether chemokines act primarily as growth factors and chemoattractants for primary and metastatizing tumors, respectively. Research of recent years, using gene knockout mice, recombinant chemokines, and agents able to block chemokine actions, has provided further insight into the diverse functions of chemokines. Here, we review the current knowledge on the complex actions of chemokines at the interface of the immune system and the tumor.
机译:趋化因子是参与免疫细胞迁移和体内平衡的关键分子。但是,肿瘤细胞也将趋化因子信号用于不同的过程,例如肿瘤的进展和转移。因此,尚不清楚趋化因子是否通过其免疫刺激作用通过肿瘤免疫监视而有助于抑制肿瘤细胞,或者趋化因子是否主要分别充当原发性和转移性肿瘤的生长因子和趋化因子。近年来,使用基因敲除小鼠,重组趋化因子和能够阻断趋化因子作用的药物的研究为趋化因子的多种功能提供了进一步的见识。在这里,我们回顾了有关趋化因子在免疫系统和肿瘤之间的复杂作用的最新知识。

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