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首页> 外文期刊>Sexually Transmitted Infections >Randomised controlled trial on whether advance knowledge of prostate-specific antigen testing improves participant reporting of unprotected sex.
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Randomised controlled trial on whether advance knowledge of prostate-specific antigen testing improves participant reporting of unprotected sex.

机译：关于前列腺特异性抗原检测的预先知识是否能改善参与者报告未保护性行为的随机对照试验。

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OBJECTIVES: To determine whether the process of informing research participants that they would be tested for the presence of a biological marker of semen exposure would reduce bias in their reports of unprotected sex. METHODS: A randomised trial of 210 female sex workers from Mombasa, Kenya, was conducted, where half the group had advance knowledge (via the request for informed consent) that they would be tested for prostate-specific antigen (PSA) in their vaginal fluid before they reported on sex and condom use for the past 48 h. The other half were invited to participate (via additional informed consent) in the test for PSA after they had already consented to be questioned and reported on these sexual behaviours. A trained nurse instructed participants to self-swab to collect vaginal fluid specimens, which were tested for PSA using ELISA. RESULTS: Reporting of unprotected sex did not differ between those with advance knowledge of the test for PSA and those without this knowledge (14.3% v 11.4%, respectively; p = 0.27). Surprisingly, more women with advance knowledge (15.8%) had discrepant self reports and PSA results than women without advance knowledge (9.1%); however, the difference was not statistically significant (OR 1.9; 95% CI 0.8 to 4.5). CONCLUSIONS: Knowing that one's answers to a questionnaire could be verified with a biological marker of semen exposure did not make respondents more likely to report unprotected sex.
机译：目的：确定告知研究参与者将对他们进行精液暴露生物标志物测试的过程是否可以减少其无保护性行为报告中的偏见。方法：对来自肯尼亚蒙巴萨的210名女性性工作者进行了一项随机试验，该小组中有一半的人事先了解（通过知情同意的要求）他们将在阴道液中接受前列腺特异性抗原（PSA）的检测。在他们报告过去48小时内性和安全套使用情况之前。另一半已被征询并报告了这些性行为，因此被邀请（通过额外的知情同意）参加PSA测试。一名训练有素的护士指示参与者自我抽检以收集阴道液体标本，并使用ELISA对这些标本进行PSA测试。结果：那些事先了解PSA测试知识的人和没有此知识的人之间未保护性行为的报告没有差异（分别为14.3％对11.4％; p = 0.27）。出人意料的是，拥有高超知识的女性（15.8％）比没有高深知识的女性（9.1％）的自我报告和PSA结果不一致;然而，差异无统计学意义（OR 1.9; 95％CI 0.8至4.5）。结论：知道可以用生物学指标检测精液来证实对问卷的回答，但这并不会使受访者更有可能报告未保护的性行为。

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