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首页> 外文期刊>Seminars in reproductive medicine >Prostaglandin F2alpha and its receptor as activators of human decidua.
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Prostaglandin F2alpha and its receptor as activators of human decidua.

机译：前列腺素F2alpha及其受体作为人类蜕膜的激活剂。

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摘要

Prostaglandins produced by the intrauterine tissues of both mother and fetus (myometrium, decidua, placenta, chorion, and amnion) are involved with all of the physiologies of parturition (membrane rupture, cervical dilatation, myometrial contractility, placental separation, and uterine involution). For parturition to occur, however, the intrauterine tissues need to first be activated to prepare for the work of labor, then stimulated to initiate labor. Prostaglandins normally are considered to be stimulators of the physiologies of labor. This review presents evidence that one prostaglandin, PGF2alpha, and its receptor, FP, are also activators, especially of the decidua. Stimulated by cytokines, the decidual synthesis of PGF2alpha and the expression of FP lead to increased matrix metalloproteinase activity, further enhancement of cytokine activity, increased decidual oxytocin and oxytocin receptor expression, decreased progesterone responsiveness, and possibly, enhanced expression of vascular endothelialgrowth factor. These collective actions prepare the decidua for its role in parturition.
机译：由母亲和胎儿的子宫内组织（子宫内膜，蜕膜，胎盘，绒毛膜和羊膜）产生的前列腺素与所有的分娩生理（膜破裂，宫颈扩张，肌层收缩力，胎盘分离和子宫复旧）有关。但是，要发生分娩，首先需要激活子宫内组织以准备分娩，然后再刺激分娩。前列腺素通常被认为是劳动生理的刺激物。这项审查提供证据，前列腺素PGF2alpha及其受体FP也是活化剂，尤其是蜕膜的活化剂。受细胞因子刺激，PGF2alpha的蜕膜合成和FP的表达导致基质金属蛋白酶活性增加，细胞因子活性的进一步增强，催产素和催产素受体的蜕膜含量增加，孕酮反应性降低，并可能增强了血管内皮生长因子的表达。这些集体行动为蜕膜在分娩中的作用做好了准备。

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