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首页> 外文期刊>Sexually Transmitted Infections >High prevalence of macrolide resistant Treponema pallidum strains in a London centre.
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High prevalence of macrolide resistant Treponema pallidum strains in a London centre.

机译：在伦敦市中心，大环内酯类耐药性梅毒螺旋体菌株的患病率很高。

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OBJECTIVES: Macrolide resistant Treponema pallidum strains, caused by mutations in the 23S ribosomal RNA (23S rRNA) gene, are widespread and increasingly prevalent. The authors aimed to establish the strain types of T pallidum isolated from patients in a London sexual health centre and to determine the frequency of macrolide resistance. METHODS: T pallidum DNA from blood and ulcer samples were subjected to strain typing and mutation analysis using previously described methods. RESULTS: 18 samples were tested and a 23S rRNA point mutation conferring macrolide resistance was found in 66.6%. All resistant strains were collected from men who have sex with men and both the A2058G and the A2059G mutations were found. Two strain types were identified (14d/g and 14d/f); the predominant strain type was 14d/g and an association was noted between tp0548 type g and macrolide resistance. CONCLUSIONS: High levels of T pallidum macrolide resistance are present in London, UK, and this has clear implications for national treatment guidelines.
机译：目的：由23S核糖体RNA（23S rRNA）基因突变引起的大环内酯类耐药性梅毒螺旋体菌株已广泛传播并日益流行。作者的目的是确定从伦敦性健康中心的患者中分离出的苍白丁香的菌株类型，并确定大环内酯类药物耐药的频率。方法：使用先前描述的方法对血液和溃疡样品中的苍白T DNA进行菌株分型和突变分析。结果：检测了18个样品，发现66.6％的大环内酯类耐药性的23S rRNA点突变。从与男性发生性关系的男性中收集了所有抗性菌株，并且发现了A2058G和A2059G突变。确定了两种菌株类型（14d / g和14d / f）;主要菌株类型为14d / g，并且在tp0548 g类型与大环内酯耐药性之间存在关联。结论：英国伦敦存在高水平的T pallidum大环内酯耐药性，这对国民治疗指南具有明显的意义。

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