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首页> 外文期刊>Sexually Transmitted Infections >A multi-centre evaluation of nine rapid, point-of-care syphilis tests using archived sera.
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A multi-centre evaluation of nine rapid, point-of-care syphilis tests using archived sera.

机译：使用存档的血清对九项快速即时梅毒测试进行多中心评估。

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OBJECTIVES: To evaluate nine rapid syphilis tests at eight geographically diverse laboratory sites for their performance and operational characteristics. METHODS: Tests were compared "head to head" using locally assembled panels of 100 archived (50 positive and 50 negative) sera at each site using as reference standards the Treponema pallidum haemagglutination or the T pallidum particle agglutination test. In addition inter-site variation, result stability, test reproducibility and test operational characteristics were assessed. RESULTS: All nine tests gave good performance relative to the reference standard with sensitivities ranging from 84.5-97.7% and specificities from 84.5-98%. Result stability was variable if result reading was delayed past the recommended period. All the tests were found to be easy to use, especially the lateral flow tests. CONCLUSIONS: All the tests evaluated have acceptable performance characteristics and could make an impact on the control of syphilis. Tests that can use whole blood and do not require refrigeration were selected for further evaluation in field settings.
机译：目的：评估在八个地理位置不同的实验室站点进行的九项梅毒快速检测的性能和操作特性。方法：使用梅毒螺旋体血细胞凝集试验或苍白球T颗粒凝集试验作为参考标准，使用每个位置上100份存档（50份阳性和50份阴性）血清的本地组装面板“头对头”比较测试。此外，还评估了站点间的差异，结果稳定性，测试可重复性和测试操作特性。结果：相对于参考标准，所有九项测试均具有良好的性能，灵敏度为84.5-97.7％，特异性为84.5-98％。如果结果读取延迟超过建议时间，则结果稳定性会有所不同。发现所有测试都易于使用，尤其是横向流动测试。结论：所有评估的测试均具有可接受的性能特征，并且可能对梅毒的控制产生影响。选择了可以使用全血且不需要冷藏的测试，以便在现场进行进一步评估。

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