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Efficient Radioisotope Energy Transfer by Gold Nanoclusters for Molecular Imaging

机译：金纳米团簇用于分子成像的高效放射性同位素能量转移

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摘要

Beta-emitting isotopes Fluorine-18 and Yttrium-90 are tested for their potential to stimulate gold nanoclusters conjugated with blood serum proteins (AuNCs). AuNCs excited by either medical radioisotope are found to be highly effective ionizing radiation energy transfer mediators, suitable for in vivo optical imaging. AuNCs synthesized with protein templates convert beta-decaying radioisotope energy into tissue-penetrating optical signals between 620 and 800 nm. Optical signals are not detected from AuNCs incubated with Technetium-99m, a pure gamma emitter that is used as a control. Optical emission from AuNCs is not proportional to Cerenkov radiation, indicating that the energy transfer between the radionuclide and AuNC is only partially mediated by Cerenkov photons. A direct Coulombic interaction is proposed as a novel and significant mechanism of energy transfer between decaying radionuclides and AuNCs.
机译：测试了发射β的同位素Fluorine-18和Yttrium-90刺激与血清蛋白（AuNCs）结合的金纳米簇的潜力。发现被任一医学放射性同位素激发的AuNCs是高效电离辐射能转移介质，适用于体内光学成像。用蛋白质模板合成的AuNCs将衰减β的放射性同位素能量转换为620至800 nm之间的穿透组织的光信号。从与Technetium-99m（用作控件的纯伽马发射器）一起孵育的AuNC中未检测到光信号。 AuNCs的光发射与切伦科夫辐射不成比例，表明放射性核素与AuNC之间的能量转移仅部分由切伦科夫光子介导。提出了一种直接的库伦相互作用，作为一种新型的重要的衰变放射性核素与AuNCs之间的能量转移机制。

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