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首页> 外文期刊>Skeletal radiology >A case of paravertebral mediastinal chordoma without bone destruction
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A case of paravertebral mediastinal chordoma without bone destruction

机译：椎旁纵隔脊索瘤无骨破坏一例

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摘要

We report a unique case of mediastinal paravertebral chordoma without bone destruction in a 47-year-old Japanese woman. She was admitted to hospital after a tumor was incidentally detected on a chest radiograph. The tumor was located in the paravertebral region of the mediastinum and did not show any destruction of the thoracic vertebra radiologically. The tumor was clinically diagnosed as a benign neurogenic tumor and the tumor was easily removed surgically. Microscopically, the tumor mainly consisted of tumor cells with extensively vacuolated cytoplasm, arranged in cord- and nest-like fashion against a myxoid matrix background. Immunohistochemically, the tumor cells showed diffuse positivity for pancytokeratin (AE1/AE3) and vimentin. The tumor cell nuclei were positive for brachyury, which is a key transcription factor of notochordal development. These results confirmed the tumor to be an extraosseous chordoma in the paravertebral mediastinal region, which is an extremely rare location for a chordoma.
机译：我们报道了一名47岁的日本女性中无骨破坏的纵隔椎旁脊索瘤的一例。在胸部X光片上偶然发现肿瘤后，她被送进医院。该肿瘤位于纵隔的椎旁区域，放射学上未显示出胸椎的任何破坏。该肿瘤在临床上被诊断为良性神经源性肿瘤，并且很容易通过外科手术切除。在显微镜下，肿瘤主要由具有广泛空泡化细胞质的肿瘤细胞组成，在粘液状基质的背景下呈帘线状和巢状排列。免疫组织化学观察，肿瘤细胞对全细胞角蛋白（AE1 / AE3）和波形蛋白呈弥散阳性。肿瘤细胞核为短臂梭菌阳性，这是脊索发育的关键转录因子。这些结果证实了该肿瘤是椎旁纵隔区域的骨外脊索瘤，这对于脊索瘤是极为罕见的位置。

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