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首页> 外文期刊>Skin pharmacology and applied skin physiology >Systemic organophosphate poisoning following the percutaneous injection of insecticide. Case report.
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Systemic organophosphate poisoning following the percutaneous injection of insecticide. Case report.

机译：经皮注射杀虫剂后全身性有机磷酸中毒。案例报告。

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Organophosphates are the most common group of chemicals in the southern part of Turkey. Although organophosphate poisoning (OPP) may occur due to skin exposure or inhalation, severe poisoning is usually the result of ingestion to attempt suicide. Despite the fact that there have been a lot of experimental studies using intravenous or percutaneous injection of organophosphates, reports of human poisoning due to percutaneous injection are rare. The systemic signs of OPP have not been described in these reported patients. We report 2 cases having systemic signs of OPP due to percutaneous injection. In our first case, we noticed a 17-day muscle weakness and a 12-day muscarinic syndrome, which required prolonged atropinization. In the second patient, atropine infusion had to be continued for 2 days. Both cases also had severe swelling of the affected limb and wound infection. In conclusion, in cases of percutaneous injection of organophosphates systemic toxicity may develop in addition to local findings such as necrosis and abscesses. Close observation for evidence of systemic involvement is required, and the patient should be carefully monitored for secondary abscess formation and any delayed impairment of neurologic function.
机译：有机磷是土耳其南部最常见的化学物质。尽管有机磷中毒（OPP）可能由于皮肤暴露或吸入而发生，但严重中毒通常是摄入企图自杀的结果。尽管有许多使用静脉内或经皮注射有机磷酸盐的实验研究，但很少有因经皮注射而导致人中毒的报道。在这些报道的患者中尚未描述OPP的全身症状。我们报告2例因经皮注射而出现OPP的全身性体征。在我们的第一个病例中，我们注意到了17天的肌肉无力和12天的毒蕈碱综合症，这需要长时间的atropinization。在第二位患者中，阿托品必须持续输注2天。这两例病例的患肢也有严重肿胀和伤口感染。总之，在经皮注射有机磷酸酯的情况下，除局部发现（如坏死和脓肿）外，还可能产生全身毒性。需要仔细观察是否有全身性受累的证据，并且应仔细监测患者的继发脓肿形成和任何延迟的神经功能损害。

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