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首页> 外文期刊>Skin research and technology: official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) >Change of biophysical properties of the skin caused by ultraviolet radiation-induced photodamage in Koreans.
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Change of biophysical properties of the skin caused by ultraviolet radiation-induced photodamage in Koreans.

机译：紫外线引起的韩国人光损伤引起的皮肤生物物理特性变化。

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摘要

BACKGROUND/PURPOSE: Ultraviolet (UV) irradiation affects the function and complexion of the skin by inducing changes in physical properties through formation of erythema, proliferation of epithelial cells, DNA damage, activation or inactivation of various enzymes and proteins, and free radical formation. In this study, the authors intended to observe the overall course of changes in barrier function and reflectance of the skin induced by photodamage, and healing reaction in the course of time, and alteration of the skin complexion. METHODS: The subjects were chosen from 15 healthy Korean men 20-35 in age, that fall into the category of Fitzpatrick's skin types II, III, and IV without history of recent exposure to sunlight, photosensitivity, or having taken any drugs that induce phototoxicity or photoallergic reactions. The subjects were artificially exposed to suberythemogenic dose [0.5 minimal erythemal dose (MED), 0.75 MED], 1 MED and high dose (2.5 MED) by solar simulator, and changes in skin barrier function and skin reflectance were assessed with a Tewameter, a Corneometer, and a Colorimeter for 4 weeks. RESULTS: Transepidermal water loss (TEWL) increased abruptly at Day 1 of single solar UV (SSUV) exposure, and slowly returned to the original level from Day 2/Day 3. In the case of exposure with 0.75 MED, it returned to the original level at Day 4 of exposure, and at Days 7 and 28 in the cases of 1 MED and 2.5 MED exposure, respectively. Water-holding capacity sharply declined at Day 1 of exposure, hitting the lowest point at Day 2, and then slowly recovered starting on Day 3. In the case of exposure with 0.75 MED and 1 MED, it returned to the original level at Days 7 and 28 in the case of 2.5 MED exposure. The a(*) values abruptly increased and reached the peak at Day 1 and slowly returned to the original level at Day 2, while the b(*) values slowly increased at Day 3, peaking at Day 7 and slowly returning to the original level thereafter. The L(*) values abruptly declined at Day 1, maintainingplateau through Day 7 and slowly returning to the baseline level thereafter. The individual typology angle (ITA degrees ) were compatible with L(*) values change. The erythema index increased abruptly at Day 1 of SSUV exposure, peaking at Day 2 and slowly returned to the original level starting at Day 3. Melanin index slowly started to increase on Day 3 of SSUV exposure, peaking at Day 7 and gradually returned to the original level thereafter. However, L(*), a(*), b(*), erythema index, and melanin index did not return to the original level during the 28-day course of this study. CONCLUSION: This study shows that in the skin of Korean subjects, changes in skin barrier function and delayed melanization do occur even in exposure to a suberythemogenic dose of SSUV. Also, given the fact that restoration of barrier function occurs as the process of melanization begins, melanization is considered to be a useful predictive indicator of the restoration of the skin barrier function after sunburn.
机译：背景/目的：紫外线（UV）通过形成红斑，上皮细胞增殖，DNA损伤，各种酶和蛋白质失活或激活以及自由基形成，引起物理性质的变化，从而影响皮肤的功能和肤色。在这项研究中，作者打算观察由光损伤引起的皮肤屏障功能和反射率变化的整体过程，以及随时间推移的愈合反应以及皮肤肤色的变化。方法：受试者选自15名年龄在20-35岁的健康韩国男性，属于Fitzpatrick的II，III和IV型皮肤，没有近期暴露于阳光下，无光敏性或服用过任何可诱发光毒性的药物或光过敏反应。通过太阳模拟器将受试者人工暴露于亚生热剂量[0.5最小红斑剂量（MED），0.75 MED]，1 MED和高剂量（2.5 MED）下，并使用Tewameter，a评估皮肤屏障功能和皮肤反射率的变化。测角仪和比色计持续4周。结果：单日紫外线（SSUV）暴露的第1天，表皮失水（TEWL）突然增加，并且从第2天/第3天开始缓慢恢复到原始水平。如果暴露为0.75 MED，则恢复到原始水平。分别在第1天和2.5 MED暴露的情况下，在第4天以及第7天和第28天的水平。持水量在暴露的第1天急剧下降，在第2天达到最低点，然后从第3天开始缓慢恢复。对于暴露量为0.75 MED和1 MED的情况，它在第7天恢复到原始水平。如果是2.5 MED暴露，则为28。 a（*）值突然增加并在第1天达到峰值，并在第2天缓慢恢复到原始水平，而b（*）值在第3天缓慢增加，在第7天达到峰值，然后缓慢返回原始水平。之后。 L（*）值在第1天突然下降，直到第7天都保持平稳，此后逐渐恢复到基线水平。各个类型角度（ITA度）与L（*）值的变化兼容。红斑指数在SSUV暴露的第1天突然增加，在第2天达到峰值，并从第3天开始缓慢恢复到原始水平。黑色素指数在SSUV暴露的第3天开始缓慢增加，在第7天达到峰值，然后逐渐恢复到原来的水平。此后为原始水平。但是，在这项研究的28天过程中，L（*），a（*），b（*），红斑指数和黑色素指数没有恢复到原始水平。结论：这项研究表明，在韩国受试者的皮肤中，即使暴露于亚生热剂量的SSUV中，皮肤屏障功能的改变和黑化延迟也确实发生。同样，考虑到随着黑化过程的开始，屏障功能的恢复会发生，因此，黑化被认为是晒伤后皮肤屏障功能恢复的有用预测指标。

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