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首页> 外文期刊>Skin pharmacology and physiology >Investigation of Model Sunscreen Formulations Comparing the Sun Protection Factor, the Universal Sun Protection Factor and the Radical Formation Ratio
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Investigation of Model Sunscreen Formulations Comparing the Sun Protection Factor, the Universal Sun Protection Factor and the Radical Formation Ratio

机译：比较防晒系数，通用防晒系数和自由基形成比的防晒配方模型的研究

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摘要

In view of globally rising skin cancer rates and harmful effects exerted by sunlight throughout the ultraviolet, visible and infrared ranges, an objective, safe and comprehensive method for determining sunscreen efficacy is required in order to warrant safe sun exposure. In this study, the influence of characteristic active ingredients (chemical filters, physical filters and antioxidants) on different sunscreen indicators, including the universal sun protection factor and the radical formation ratio, was determined and compared to their influence on sun protection factor values. Spectroscopic universal sun protection factor measurements were conducted ex vivo by analyzing tape strips taken from human skin, and radical formation ratio determination was performed via electron paramagnetic resonance spectroscopy using porcine ear skin ex vivo. The sun protection factor determination was conducted according to ISO standards (ISO 24444: 2010). It was shown that chemical filters provide a protective effect which was measurable by all methods examined (spectroscopy, electron paramagnetic resonance spectroscopy and erythema formation). Physical filters, when used as single active ingredients, increased protective values in universal sun protection factor and sun protection factor measurements but exhibited no significant effect on universal sun protection factor measurements when used in combination with chemical filters or antioxidants. Antioxidants were shown to increase sun protection factor values. Radical formation ratio values were shown to be influenced merely by chemical filters, leading to the conclusion that the universal sun protection factor is the most suitable efficacy indicator for the ultraviolet range. (C) 2015 S. Karger AG, Basel
机译：鉴于全球皮肤癌发病率上升以及日光在紫外线，可见光和红外光范围内产生的有害影响，需要一种客观，安全和全面的方法来确定防晒功效，以确保安全的日光照射。在这项研究中，确定了特征活性成分（化学过滤器，物理过滤器和抗氧化剂）对不同防晒剂指标的影响，包括通用防晒系数和自由基形成率，并将其与防晒系数值的影响进行比较。通过分析从人皮肤上取下的胶带，进行离体的光谱通用防晒系数测量，离体使用猪耳朵皮肤通过电子顺磁共振波谱测定自由基形成率。防晒系数的确定是根据ISO标准（ISO 24444：2010）进行的。结果表明，化学过滤器具有保护作用，可以通过所有检查的方法（光谱法，电子顺磁共振光谱法和红斑形成）进行测量。物理过滤器作为单一活性成分使用时，可以提高通用防晒系数和防晒系数测量的保护值，但与化学过滤器或抗氧化剂组合使用时，对通用防晒系数的测量没有显着影响。已证明抗氧化剂可增加防晒系数值。自由基形成比率值仅受化学过滤器影响，得出结论，通用防晒系数是紫外线范围最合适的功效指标。 （C）2015 S.Karger AG，巴塞尔

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