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首页> 外文期刊>Biological chemistry >15-Lipoxygenase-1: A Prooxidant Enzyme
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15-Lipoxygenase-1: A Prooxidant Enzyme

机译：15-Lipoxygenase-1：一种抗氧化酶

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摘要

Human and rabbit reticulocyte 15-lipoxygenase (15-lipoxygenase-1) and the leukocyte-type 12-lipoxygenases (12/15-lipoxygenases) of pig, beef, mouse and rat constitute a particular subfamily of mammalian lipoxygenases (reticulocyte-type lipoxygenases) with unique properties and functions. They catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Moreover, they are a source of free radicals initiating non-enzymatic lipid peroxidation and other oxidative processes. Expression and activity of reticulocyte-type lipoxygenases are highly regulated. Moreover, the susceptibility of intracellular membranes toward these lipoxygenases is controlled and may be increased together with lipoxygenase activity under conditions of oxidative stress. Thus, oxidative stress may favor a concerted package of lipoxygenase-mediated enzymatic and non-enzymatic lipid peroxidation and co-oxidative processes. Reaction of reticulocyte-type lipoxygenases with low-density lipoprotein renders the latter atherogenic and appears to be involved in the formation of atherosclerotic lesions.
机译：猪，牛肉，小鼠和大鼠的人和兔网织红细胞15-脂氧合酶（15-lipoxygenase-1）和白细胞型12-脂氧合酶（12 / 15-脂氧合酶）构成了哺乳动物脂氧合酶的一个特定亚家族（网织红细胞型脂氧合酶）具有独特的特性和功能。它们通过生物膜和血浆脂蛋白的磷脂和胆固醇酯的直接双氧合催化复杂生物结构中的酶脂质过氧化。此外，它们是引发非酶脂质过氧化和其他氧化过程的自由基的来源。网状细胞型脂氧合酶的表达和活性受到高度调节。此外，细胞内膜对这些脂氧合酶的敏感性受到控制，并且在氧化应激条件下可与脂氧合酶活性一起增加。因此，氧化应激可能有利于脂加氧酶介导的酶促和非酶促脂质过氧化和共氧化过程的协同包装。网状细胞型脂氧合酶与低密度脂蛋白的反应使后者发生动脉粥样硬化，并似乎参与了动脉粥样硬化病变的形成。

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