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首页> 外文期刊>Signal transduction: Receptors, mediators and genes: Official journal of the Signal Transduction Society >The stoichiometry of the T cell antigen receptor and its implications for the signal transduction mechanism
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The stoichiometry of the T cell antigen receptor and its implications for the signal transduction mechanism

机译：T细胞抗原受体的化学计量及其对信号转导机制的影响

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摘要

The T cell antigen receptor (TCR·CD3) is a multi-subunit complex mediating T cell development and activation. The molecular mechanism of how this receptor transmits information across the membrane is still an enigma. The stoichiometry and architecture of this receptor in the membrane are under intense investigation, since they are important in deciphering the signal transduction mechanism of the TCR·CD3. This review highlights the evidence that TCR·CD3 is found on unstimulated T cells in monovalent (one ligand-binding site per receptor) as well as in multivalent forms. Distinct detergents affect the integrity of the multivalent receptor differently, explaining controversial findings of TCR·CD3 stoichiometries as determined by biochemical means. The existence of multivalent receptors is not compatible with current models of TCR·CD3 triggering. Therefore, I discuss the novel permissive geometry model that combines multivalent TCR·CD3s, the requirement for multimeric ligands for receptor triggering and conformational changes at CD3.
机译：T细胞抗原受体（TCR·CD3）是介导T细胞发育和激活的多亚基复合物。该受体如何跨膜传递信息的分子机制仍然是一个谜。膜中该受体的化学计量和结构正在深入研究中，因为它们在解密TCR·CD3的信号转导机制中很重要。这篇综述强调了证据表明，TCR·CD3以单价（每个受体一个配体结合位点）以及多价形式存在于未刺激的T细胞上。不同的去污剂对多价受体完整性的影响不同，这解释了通过生化手段确定的TCR·CD3化学计量比的有争议的发现。多价受体的存在与当前TCR·CD3触发模型不兼容。因此，我将讨论结合多价TCR·CD3s的新颖的容许几何模型，这是CD3受体触发和构象变化所需要的多聚体配体。

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