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首页> 外文期刊>ORL: Journal for oto-rhino-laryngology and its borderlands >Association of the -1438G/A polymorphism of the 5-HT2A receptor gene with obstructive sleep apnea syndrome.
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Association of the -1438G/A polymorphism of the 5-HT2A receptor gene with obstructive sleep apnea syndrome.

机译：5-HT2A受体基因的-1438G / A多态性与阻塞性睡眠呼吸暂停综合症的关联。

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OBJECTIVE: Serotonergic neurons innervating motoneurons increase their firing rates in response to respiratory challenges, and long-term facilitation of respiratory activity in response to hypoxia is serotonin (5-HT) dependent. Polymorphism of the genes which code for 5-HT receptors may affect functions of the serotonergic system, and may be associated with obstructive sleep apnea syndrome (OSAS). The objective in this study was to assess the significance of T102C and -1438G/A polymorphisms of the 5-HT2A receptor gene in OSAS. METHODS: Fifty-five patients with OSAS and 102 healthy volun teers were included for genetic analyses of T102C and -1438G/A polymorphisms of the 5-HT2A receptor gene. RESULTS: For the T102C polymorphism, there was no significant difference between the patients and controls and both genders (p > 0.05). For the -1438G/A polymorphism, the A/A and G/A genotypes were overrepresented in the patients and controls, respectively (p = 0.045). In the control group, the genotypes of both genders were not significantly different (p > 0.05). In the patients, the A/A and G/A genotypes were overrepresented in males and females, respectively (p = 0.035). Concerning males, the A/A genotype was overrepresented in patients (p = 0.007). CONCLUSION: Serotonergic mechanisms appear to be related to OSAS. The T102C polymorphism of the 5-HT2A receptor gene is not associated with OSAS. However, the -1438G/A polymorphism is associated with OSAS occurrence, especially in male patients. This polymorphism may also be associated with different OSAS incidences of both genders.
机译：目的：支配运动神经元的5-羟色胺能神经元可响应呼吸挑战提高其放电频率，而长期缺氧反应对呼吸活动的促进则取决于5-羟色胺（5-HT）。编码5-HT受体的基因的多态性可能影响血清素能系统的功能，并可能与阻塞性睡眠呼吸暂停综合症（OSAS）有关。这项研究的目的是评估OSAS中5-HT2A受体基因的T102C和-1438G / A多态性的重要性。方法：纳入55名OSAS患者和102名健康志愿者，对T102C和5-HT2A受体基因的-1438G / A多态性进行遗传分析。结果：对于T102C多态性，患者和对照组与男女之间均无显着差异（p> 0.05）。对于-1438G / A多态性，患者和对照组的A / A和G / A基因型分别过高（p = 0.045）。在对照组中，两种性别的基因型没有显着差异（p> 0.05）。在患者中，男性和女性的A / A和G / A基因型分别过高（p = 0.035）。对于男性，A / A基因型在患者中过高（p = 0.007）。结论：血清素能机制似乎与OSAS有关。 5-HT2A受体基因的T102C多态性与OSAS不相关。但是，-1438G / A多态性与OSAS的发生有关，特别是在男性患者中。这种多态性也可能与男女的OSAS发生率不同有关。

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