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首页> 外文期刊>ORL: Journal for oto-rhino-laryngology and its borderlands >Epithelial changes in seasonal allergic rhinitis throughout the year: evidence of coexistent air pollution and local secretory IgA deficiency?
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Epithelial changes in seasonal allergic rhinitis throughout the year: evidence of coexistent air pollution and local secretory IgA deficiency?

机译：全年季节性变应性鼻炎的上皮变化：空气污染和局部分泌型IgA缺乏症并存的证据？

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摘要

To determine possible epithelial changes in seasonal allergic rhinitis, we examined epithelial cells in cytology swab preparations of 38 non-smoking patients, exclusively sensitized to grass pollen, throughout the year, and surgical material of 8 patients. Cytologically, we found a marked goblet cell hyperplasia during the period of grass pollen exposure, while meta- and dysplasia were found throughout the year. Immunohistochemically, a lack of secretroy IgA in the altered epithelium was detected. These results were not obtained in the control group of 60 healthy non-smokers. Since we have recently found the same epithelial changes of meta- and dysplasia in smokers, these findings may point to non-specific toxic damage of the nasal epithelium possibly caused by other air pollutants. The altered epithelium may lead to an impairment of the local secretory IgA defence system and thereby to an increased allergen uptake. Copyright 2000 S. Karger AG, Basel
机译：为了确定季节性变应性鼻炎的可能上皮变化，我们检查了38例非吸烟患者的细胞学拭子制剂中的上皮细胞，这些患者全年仅对草花粉致敏，并检查了8例患者的手术材料。在细胞学上，我们在草粉接触期间发现了明显的杯状细胞增生，而全年都发现了变态和不典型增生。免疫组织化学检测到改变的上皮中缺乏分泌型IgA。在60名健康非吸烟者的对照组中未获得这些结果。由于我们最近在吸烟者中发现了上皮化生和异型增生的相同上皮变化，因此这些发现可能表明可能是由其他空气污染物引起的鼻上皮的非特异性毒性损伤。上皮的改变可能导致局部分泌型IgA防御系统受损，从而导致过敏原摄取增加。版权所有2000 S. Karger AG，巴塞尔

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