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首页> 外文期刊>South African medical journal: Suid-Afrikaanse tydskrif vir geneeskunde >Clinically significant anaerobic bacteria isolated from patients in a South African academic hospital - antimicrobial susceptibility testing
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Clinically significant anaerobic bacteria isolated from patients in a South African academic hospital - antimicrobial susceptibility testing

机译：从南非一家学术医院的患者中分离出的临床上重要的厌氧菌-药敏试验

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Background. Increasing resistance to some antimicrobial agents among anaerobic bacteria has made susceptibility patterns less predictable. Method. This was a prospective study of the susceptibility data of anaerobic organisms isolated from clinical specimens from patients with suspected anaerobic infections from June 2005 until February 2007. Specimens were submitted to the microbiology laboratory at Charlotte Maxeke Johannesburg Academic Hospital, where microscopy, culture and susceptibility testing were performed the using E test ? strip minimum inhibitory concentration method. Results were interpreted with reference to Clinical and Laboratory Standards Institute guidelines for amoxicillin-clavulanate, clindamycin, metronidazole, penicillin, ertapenem, cefoxitin, ceftriaxone, chloramphenicol and piperacillin-tazobactam. Results. One hundred and eighty anaerobic isolates were submitted from 165 patients. The most active antimicrobial agents were chloramphenicol (100% susceptible), ertapenem (97.2%), piperacillin-tazobactam (99.4%) and amoxicillin-clavulanic acid (96.7%). Less active were metronidazole (89.4%), cefoxitin (85%), clindamycin (81.7%), ceftriaxone (68.3%) and penicillin (33.3%). Conclusion. Susceptibility testing should be performed periodically to identify emerging trends in resistance and to modify empirical treatment of anaerobic infections.
机译：背景。厌氧细菌对某些抗菌剂的抗药性增强使得药敏模式难以预测。方法。这是一项前瞻性研究，从2005年6月至2007年2月从怀疑患有厌氧菌感染的患者的临床标本中分离出厌氧菌的敏感性数据。标本已提交至夏洛特·马克西克·约翰内斯堡学术医院的微生物实验室，在此进行显微镜，培养和药敏试验使用E测试进行了？剥离最小抑菌浓度法。参考阿莫西林-克拉维酸盐，克林霉素，甲硝唑，青霉素，厄他培南，头孢西丁，头孢曲松，氯霉素和哌拉西林-他唑巴坦的临床和实验室标准协会指南对结果进行解释。结果。从165例患者中分离出180株厌氧菌。活性最高的抗菌剂是氯霉素（100％敏感），厄他培南（97.2％），哌拉西林-他唑巴坦（99.4％）和阿莫西林-克拉维酸（96.7％）。甲硝唑（89.4％），头孢西丁（85％），克林霉素（81.7％），头孢曲松（68.3％）和青霉素（33.3％）的活性较低。结论。应定期进行药敏试验，以发现耐药性的新趋势并修改厌氧感染的经验治疗。

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